scholarly journals Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle.

1996 ◽  
Vol 93 (17) ◽  
pp. 8999-9003 ◽  
Author(s):  
A. Weisberg ◽  
S. Winegrad
Keyword(s):  
Cardiac Muscle ◽  
Protein C ◽  
Binding Protein ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
Cross Bridges

scholarly journals Hypercontractile Properties of Cardiac Muscle Fibers in a Knock-in Mouse Model of Cardiac Myosin-binding Protein-C

2000 ◽  
Vol 276 (7) ◽  
pp. 5353-5359 ◽  
Author(s):  
Christian C. Witt ◽  
Brenda Gerull ◽  
Michael J. Davies ◽  
Thomas Centner ◽  
Wolfgang A. Linke ◽  
...  
Keyword(s):  
Mouse Model ◽  
Cardiac Muscle ◽  
Protein C ◽  
Binding Protein ◽  
Muscle Fibers ◽  
Cardiac Myosin ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
Cardiac Muscle Fibers

scholarly journals Roles of phosphorylation of myosin binding protein-C and troponin I in mouse cardiac muscle twitch dynamics

2004 ◽  
Vol 558 (3) ◽  
pp. 927-941 ◽  
Author(s):  
Carl W. Tong ◽  
Robert D. Gaffin ◽  
David C. Zawieja ◽  
Mariappan Muthuchamy
Keyword(s):  
Cardiac Muscle ◽  
Protein C ◽  
Troponin I ◽  
Binding Protein ◽  
Muscle Twitch ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding

Effect of Extracellular CA on the Phosphorylation of Myosin Binding Protein C. In Cardiac Muscle and the Phosphorylation on Force Generation

2000 ◽  
Vol 6 (S2) ◽  
pp. 74-75
Author(s):  
S. Winegrad ◽  
I. Kulikavskaya ◽  
G. McClellan
Keyword(s):  
Cardiac Muscle ◽  
Binding Sites ◽  
Protein C ◽  
Contractile Activity ◽  
Binding Protein ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
Physiological Reactions ◽  
Binding Subunit

The affinity of the binding sites on troponin C (TNC) for Ca is sensitive to the state of phosporylation of troponin 1 (TN1). Two and possibly three other myofilament proteins can be phosphorylated by physiological reactions: the mosin binding protein C (MyBP-C), the regulatory light chain of myosin (RLC), and the tropomyosin binding subunit of troponin (TNT). In MyBP-C, the phosphorylation sites are specific for cardiac muscle, an occurrence that suggests a function unique to cardiac muscle. Phosphorylation of MyBP-C and RLC can be produced by Ca regulated kinases present in the myofibrils. Phosphorylation of RLC produces an increase in Ca sensitivity of contraction at submaximal concentrations of Ca without alteration of the maximum Ca activated force (Fmax). Absence of contractile activity decreases phosphorylation of RLC. One to two hours of quiescence in normal extracellular Ca reduces phophorylation substantially, and the level rises slowly when contractile activity is resumed.

scholarly journals In the eye of the STORM: Tracking the myosin-binding protein C N terminus in heart muscle

2021 ◽  
Vol 153 (3) ◽  
Author(s):  
Brett A. Colson
Keyword(s):  
Cardiac Muscle ◽  
Heart Muscle ◽  
Protein C ◽  
Binding Protein ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Storm Tracking ◽  
N Terminus ◽  
Myosin Binding

Colson discusses a recent investigation of the localization of N-terminal myosin-binding protein C in cardiac muscle.

scholarly journals Phosphorylation of Myosin Binding Protein-C Alters the Proximity of Cross-Bridges to Actin and Accelerates Myocardial Twitch Kinetics

2010 ◽  
Vol 98 (3) ◽  
pp. 347a
Author(s):  
Brett A. Colson ◽  
Peter P. Schemmel ◽  
Peter P. Chen ◽  
Tanya Bekyarova ◽  
Daniel P. Fitzsimons ◽  
...  
Keyword(s):  
Protein C ◽  
Binding Protein ◽  
Myosin Binding Protein ◽  
Myosin Binding Protein C ◽  
Myosin Binding ◽  
Cross Bridges
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