scholarly journals Isolation and Characterization of ARA160 as the First Androgen Receptor N-terminal-associated Coactivator in Human Prostate Cells

1999 ◽  
Vol 274 (32) ◽  
pp. 22373-22379 ◽  
Author(s):  
Pei-Wen Hsiao ◽  
Chawnshang Chang
Keyword(s):  
Androgen Receptor ◽  
Human Prostate ◽  
Prostate Cells ◽  
Isolation And Characterization

Physicochemical Characterization of the Androgen Receptor From Hyperplastic Human Prostate

1985 ◽  
Vol 133 (5) ◽  
pp. 926-927
Author(s):  
L.R. Murthy ◽  
C.H. Chang ◽  
D.R. Rowley ◽  
P.T. Scardino ◽  
D.J. Tindall
Keyword(s):  
Androgen Receptor ◽  
Physicochemical Characterization ◽  
Human Prostate

scholarly journals Androgen receptor localisation and turnover in human prostate epithelium treated with the antiandrogen, casodex

2000 ◽  
Vol 24 (3) ◽  
pp. 339-351 ◽  
Author(s):  
AS Waller ◽  
RM Sharrard ◽  
P Berthon ◽  
NJ Maitland
Keyword(s):  
Androgen Receptor ◽  
In Vitro Models ◽  
Human Prostate ◽  
Intracellular Targeting ◽  
Natural Ligand ◽  
Prostate Cells ◽  
Established Cell ◽  
Prostatic Epithelium ◽  
Prostate Epithelium

In vitro models of normal and malignant human prostate are currently limited to a few well established cell lines that, with a single exception (LNCaP), fail to express the androgen receptor (AR) - a common characteristic of prostatic epithelium grown in culture. To investigate the molecular mechanism of action of the non-steroidal antiandrogen Casodex (bicalutamide) against wild-type AR, we have established a transient AR expression model in non-tumorigenic prostate cells of both epithelial and mesenchymal origin. In this model, both dihydrotestosterone and Casodex can effectively transport the AR protein into the nucleus of prostate cells. Whereas the natural ligand, dihydrotestosterone, stabilises the receptor, the AR is rapidly degraded at a nuclear location when the transfected cells are treated with Casodex. In contrast, whereas the mutant AR in the LNCaP line is also degraded on Casodex treatment over the same time period, its intracellular targeting is defective.

scholarly journals Cloning and Characterization of Androgen Receptor Coactivator, ARA55, in Human Prostate

1999 ◽  
Vol 274 (12) ◽  
pp. 8316-8321 ◽  
Author(s):  
Naohiro Fujimoto ◽  
Shuyuan Yeh ◽  
Hong-Yo Kang ◽  
Shigeki Inui ◽  
Hong-Chiang Chang ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Human Prostate

scholarly journals Cloning and Characterization of Human Prostate Coactivator ARA54, a Novel Protein That Associates with the Androgen Receptor

1999 ◽  
Vol 274 (13) ◽  
pp. 8570-8576 ◽  
Author(s):  
Hong-Yo Kang ◽  
Shuyuan Yeh ◽  
Naohiro Fujimoto ◽  
Chawnshang Chang
Keyword(s):  
Androgen Receptor ◽  
Human Prostate ◽  
Novel Protein
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