scholarly journals Human Fatty Acid Transport Protein 2a/Very Long Chain Acyl-CoA Synthetase 1 (FATP2a/Acsvl1) Has a Preference in Mediating the Channeling of Exogenous n-3 Fatty Acids into Phosphatidylinositol

2011 ◽  
Vol 286 (35) ◽  
pp. 30670-30679 ◽  
Author(s):  
Elaina M. Melton ◽  
Ronald L. Cerny ◽  
Paul A. Watkins ◽  
Concetta C. DiRusso ◽  
Paul N. Black
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Chain Acyl ◽  
Long Chain

scholarly journals Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPARα-regulated genes

2020 ◽  
Vol 295 (17) ◽  
pp. 5737-5750 ◽  
Author(s):  
Vincent M. Perez ◽  
Jeffrey Gabell ◽  
Mark Behrens ◽  
Nishikant Wase ◽  
Concetta C. DiRusso ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Transport Protein ◽  
Transcriptomic Analysis ◽  
Fatty Acid Transport ◽  
Long Chain Fatty Acids ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Long Chain ◽  
Chain Fatty Acids

Fatty acid transport protein 2 (FATP2) is highly expressed in the liver, small intestine, and kidney, where it functions in both the transport of exogenous long-chain fatty acids and the activation of very-long-chain fatty acids. Here, using a murine model, we investigated the phenotypic impacts of deleting FATP2, followed by a transcriptomic analysis using unbiased RNA-Seq to identify concomitant changes in the liver transcriptome. WT and FATP2-null (Fatp2−/−) mice (5 weeks) were maintained on a standard chow diet for 6 weeks. The Fatp2−/− mice had reduced weight gain, lowered serum triglyceride, and increased serum cholesterol levels and attenuated dietary fatty acid absorption. Transcriptomic analysis of the liver revealed 258 differentially expressed genes in male Fatp2−/− mice and a total of 91 in female Fatp2−/− mice. These genes mapped to the following gene ontology categories: fatty acid degradation, peroxisome biogenesis, fatty acid synthesis, and retinol and arachidonic acid metabolism. Targeted RT-quantitative PCR verified the altered expression of selected genes. Of note, most of the genes with increased expression were known to be regulated by peroxisome proliferator–activated receptor α (PPARα), suggesting that FATP2 activity is linked to a PPARα-specific proximal ligand. Targeted metabolomic experiments in the Fatp2−/− liver revealed increases of total C16:0, C16:1, and C18:1 fatty acids; increases in lipoxin A4 and prostaglandin J2; and a decrease in 20-hydroxyeicosatetraenoic acid. We conclude that the expression of FATP2 in the liver broadly affects the metabolic landscape through PPARα, indicating that FATP2 provides an important role in liver lipid metabolism through its transport or activation activities.

Mouse fatty acid transport protein 4 (FATP4): Characterization of the gene and functional assessment as a very long chain acyl-CoA synthetase

Gene ◽  
2001 ◽  
Vol 270 (1-2) ◽  
pp. 31-40 ◽  
Author(s):  
Thomas Herrmann ◽  
Florian Buchkremer ◽  
Isabella Gosch ◽  
Angela M Hall ◽  
David A Bernlohr ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Functional Assessment ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Chain Acyl ◽  
Long Chain

scholarly journals The Fatty Acid Transport Protein (FATP1) Is a Very Long Chain Acyl-CoA Synthetase

1999 ◽  
Vol 274 (51) ◽  
pp. 36300-36304 ◽  
Author(s):  
Natalie Ribarik Coe ◽  
Anne Johnston Smith ◽  
Brigitte I. Frohnert ◽  
Paul A. Watkins ◽  
David A. Bernlohr
Keyword(s):  
Fatty Acid ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Chain Acyl ◽  
Long Chain

The Fatty Acid Transport Protein (FATP) Family: Very Long Chain Acyl-CoA Synthetases or Solute Carriers?

2007 ◽  
Vol 33 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Zhenzhen Jia ◽  
Zhengtong Pei ◽  
Dony Maiguel ◽  
Cicely J. Toomer ◽  
Paul A. Watkins
Keyword(s):  
Fatty Acid ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Solute Carriers ◽  
Chain Acyl ◽  
Long Chain

Characterization of the fatty acid transport protein 4 (FATP4) gene and functional assessment of FATP4 as a very long chain acyl-CoA synthetase

2001 ◽  
Vol 120 (5) ◽  
pp. A306 ◽  
Author(s):  
Thomas Herrmann ◽  
Florian Buchkremer ◽  
Isabella Gosch ◽  
Angela M. Hall ◽  
David A. Bernlohr ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Functional Assessment ◽  
Transport Protein ◽  
Fatty Acid Transport ◽  
Acid Transport ◽  
Fatty Acid Transport Protein ◽  
Chain Acyl ◽  
Long Chain
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