scholarly journals Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells

2017 ◽  
Vol 292 (52) ◽  
pp. 21527-21537 ◽  
Author(s):  
Wukui Zhao ◽  
Yikai Huang ◽  
Jingzi Zhang ◽  
Mengjie Liu ◽  
Haijing Ji ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Group Ring ◽  
Embryonic Stem ◽  
Ring Finger ◽  
Polycomb Group ◽  
Pluripotency Factor ◽  
Ring Finger Proteins

scholarly journals PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Mitsuhiro Endoh ◽  
Takaho A Endo ◽  
Jun Shinga ◽  
Katsuhiko Hayashi ◽  
Anca Farcas ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Germ Cell ◽  
Target Genes ◽  
Embryonic Stem ◽  
Ring Finger ◽  
Mouse Embryonic Stem Cells ◽  
Polycomb Group ◽  
Histone H2a ◽  
Cell Growth And Viability

The ring finger protein PCGF6 (polycomb group ring finger 6) interacts with RING1A/B and E2F6 associated factors to form a non-canonical PRC1 (polycomb repressive complex 1) known as PCGF6-PRC1. Here, we demonstrate that PCGF6-PRC1 plays a role in repressing a subset of PRC1 target genes by recruiting RING1B and mediating downstream mono-ubiquitination of histone H2A. PCGF6-PRC1 bound loci are highly enriched for promoters of germ cell-related genes in mouse embryonic stem cells (ESCs). Conditional ablation of Pcgf6 in ESCs leads to robust de-repression of such germ cell-related genes, in turn affecting cell growth and viability. We also find a role for PCGF6 in pre- and peri-implantation mouse embryonic development. We further show that a heterodimer of the transcription factors MAX and MGA recruits PCGF6 to target loci. PCGF6 thus links sequence specific target recognition by the MAX/MGA complex to PRC1-dependent transcriptional silencing of germ cell-specific genes in pluripotent stem cells.

scholarly journals Polycomb Group Protein Bmi1 Promotes Hematopoietic Cell Development from Embryonic Stem Cells

2012 ◽  
Vol 21 (1) ◽  
pp. 121-132 ◽  
Author(s):  
Xiaolei Ding ◽  
Qiong Lin ◽  
Roberto Ensenat-Waser ◽  
Stefan Rose-John ◽  
Martin Zenke
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Cell Development ◽  
Polycomb Group ◽  
Hematopoietic Cell ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals Nonoverlapping Functions of the Polycomb Group Cbx Family of Proteins in Embryonic Stem Cells

2012 ◽  
Vol 10 (1) ◽  
pp. 47-62 ◽  
Author(s):  
Lluis Morey ◽  
Gloria Pascual ◽  
Luca Cozzuto ◽  
Guglielmo Roma ◽  
Anton Wutz ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Polycomb Group

scholarly journals The polycomb group protein Yaf2 regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner

2018 ◽  
Vol 293 (33) ◽  
pp. 12793-12804 ◽  
Author(s):  
Wukui Zhao ◽  
Mengjie Liu ◽  
Haijing Ji ◽  
Yaru Zhu ◽  
Congcong Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Polycomb Group ◽  
Dependent Manner ◽  
Polycomb Group Protein ◽  
Group Protein

scholarly journals Pluripotency factor binding and Tsix expression act synergistically to repress Xist in undifferentiated embryonic stem cells

2011 ◽  
Vol 4 (1) ◽  
pp. 17 ◽  
Author(s):  
Tatyana B Nesterova ◽  
Claire E Senner ◽  
Janina Schneider ◽  
Tilly Alcayna-Stevens ◽  
Anna Tattermusch ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Factor Binding ◽  
Pluripotency Factor
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