scholarly journals Molecular Characterization of an Extended Binding Site for Coagulation Factor Va in the Positive Exosite of Activated Protein C

2002 ◽  
Vol 277 (32) ◽  
pp. 28836-28840 ◽  
Author(s):  
Andrew J. Gale ◽  
Alexander Tsavaler ◽  
John H. Griffin
Keyword(s):  
Binding Site ◽  
Molecular Characterization ◽  
Protein C ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Factor Va

scholarly journals Characterization of a Factor Xa Binding Site on Factor Va near the Arg-506 Activated Protein C Cleavage Site

2007 ◽  
Vol 282 (30) ◽  
pp. 21848-21855 ◽  
Author(s):  
Andrew J. Gale ◽  
Subramanian Yegneswaran ◽  
Xiao Xu ◽  
Jean-Luc Pellequer ◽  
John H. Griffin
Keyword(s):  
Binding Site ◽  
Cleavage Site ◽  
Protein C ◽  
Activated Protein C ◽  
Factor Xa ◽  
Factor Va

scholarly journals Enhanced Rate of Cleavage at Arg-306 and Arg-506 in Coagulation Factor Va by Gla Domain-mutated Human-activated Protein C

2004 ◽  
Vol 279 (46) ◽  
pp. 47528-47535 ◽  
Author(s):  
Yong-Hui Sun ◽  
Sinh Tran ◽  
Eva A. Norstrøm ◽  
Björn Dahlbäck
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Factor Va ◽  
Gla Domain

C4b-Binding Protein Protects Coagulation Factor Va from Inactivation by Activated Protein C†

Biochemistry ◽  
2000 ◽  
Vol 39 (47) ◽  
pp. 14543-14548 ◽  
Author(s):  
Robbert H. L. van de Poel ◽  
Joost C. M. Meijers ◽  
Jan Rosing ◽  
Guido Tans ◽  
Bonno N. Bouma
Keyword(s):  
Protein C ◽  
Binding Protein ◽  
Activated Protein C ◽  
Coagulation Factor ◽  
Factor Va

scholarly journals Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation

Blood ◽  
2015 ◽  
Vol 125 (9) ◽  
pp. 1497-1501 ◽  
Author(s):  
Yesim Dargaud ◽  
Jean Yves Scoazec ◽  
Simone J. H. Wielders ◽  
Christine Trzeciak ◽  
Tilman M. Hackeng ◽  
...  
Keyword(s):  
Protein C ◽  
Thrombin Generation ◽  
Autosomal Dominant ◽  
Activated Protein C ◽  
Bleeding Disorder ◽  
Soluble Thrombomodulin ◽  
Factor Va ◽  
Factor Viiia ◽  
Key Points

Key Points The THBD c.1611C>A mutation (p.Cys537Stop) causes extremely high soluble thrombomodulin levels resulting in trauma-related bleeding. Soluble thrombomodulin acts by enhancing activated protein C generation and by impairing factor Va, factor VIIIa, and thrombin generation.

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