scholarly journals α7Nicotinic Acetylcholine Receptors Mediate β-Amyloid Peptide-induced Tau Protein Phosphorylation

2003 ◽  
Vol 278 (34) ◽  
pp. 31547-31553 ◽  
Author(s):  
Hoau-Yan Wang ◽  
Weiwei Li ◽  
Nancy J. Benedetti ◽  
Daniel H. S. Lee
Keyword(s):  
Protein Phosphorylation ◽  
Tau Protein ◽  
Acetylcholine Receptors ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Choline Modulation of the Aβ P1-40 Channel Reconstituted into a Model Lipid Membrane

2010 ◽  
Vol 2010 ◽  
pp. 1-12
Author(s):  
Daniela Meleleo ◽  
Gabriella Notarachille ◽  
Silvia Micelli
Keyword(s):  
Lipid Bilayers ◽  
Nicotinic Acetylcholine Receptors ◽  
Acetylcholine Receptors ◽  
Lipid Membrane ◽  
Cd Spectroscopy ◽  
Amyloid Peptide ◽  
Random Coil ◽  
Ion Conductance ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Nicotinic acetylcholine receptors (AChRs), implicated in memory and learning, in subjects affected by Alzheimer's disease result altered. Stimulation of α7-nAChRs inhibits amyloid plaques and increases ACh release. β-amyloid peptide (AβP) forms ion channels in the cell and model phospholipid membranes that are retained responsible in Alzheimer disease. We tested if choline, precursor of ACh, could affect the AβP1-40 channels in oxidized cholesterol (OxCh) and in palmitoyl-oleoyl-phosphatidylcholine (POPC):Ch lipid bilayers. Choline concentrations of 5 × 10−11 M–1.5 × 10−8 M added to thecis- ortrans-side of membrane quickly increased AβP1-40 ion channel frequency (events/min) and ion conductance in OxCh membranes, but not in POPC:Ch membranes. Circular Dichroism (CD) spectroscopy shows that after 24 and 48 hours of incubation with AβP1-40, choline stabilizes the random coil conformation of the peptide, making it less prone to fibrillate. These actions seem to be specific in that ACh is ineffective either in solution or on AβP1-40 channel incorporated into PLMs.

N2L, a novel lipoic acid-niacin dimer protects HT22 cells against β-amyloid peptide-induced damage through attenuating apoptosis

2019 ◽  
Vol 34 (6) ◽  
pp. 1761-1770 ◽  
Author(s):  
Rikang Wang ◽  
Lang Zhang ◽  
Rifang Liao ◽  
Qian Li ◽  
Rongbiao Pi ◽  
...  
Keyword(s):  
Lipoic Acid ◽  
Amyloid Peptide ◽  
Ht22 Cells ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Mutagenic analysis of the nucleation propensity of oxidized Alzheimer's β-amyloid peptide

2005 ◽  
Vol 14 (8) ◽  
pp. 2125-2131 ◽  
Author(s):  
Tony Christopeit ◽  
Peter Hortschansky ◽  
Volker Schroeckh ◽  
Karlheinz Gührs ◽  
Giorgia Zandomeneghi ◽  
...  
Keyword(s):  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide
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