Massive, Life-Threatening Bleeding in Crohn’s Disease

Abstract Disseminated histoplasmosis is a life-threatening disease usually seen in immunocompromised patients living in endemic areas. We present an apparently immunocompetent patient with gastrointestinal histoplasmosis who was initially diagnosed as biopsy-proven Crohn’s disease. Following discontinuation of anti-inflammatory drugs and institution of antifungal therapy, his GI illness completely improved. Specific fungal staining should be routinely included in histopathologic assessment of tissue specimens diagnosed as Crohn’s disease.

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Acute neurologic disorder in Crohn's disease: A rare life‐threatening complication

GE Jornal Português de Gastrenterologia ◽

10.1016/j.jpg.2013.10.006 ◽

2014 ◽

Vol 21 (1) ◽

pp. 31-34 ◽

Cited By ~ 1

Author(s):

Joana Machado ◽

Paula Ministro ◽

Eugénia Cancela ◽

Ricardo Araújo ◽

António Castanheira ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Neurologic Disorder ◽

Life Threatening ◽

Life Threatening Complication

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Life-Threatening Hemorrhage: An Unusual Form of Presentation of Crohn's Disease Treated with Endoscopic Injection Sclerotherapy

Endoscopy ◽

10.1055/s-2007-1001383 ◽

1998 ◽

Vol 30 (07) ◽

pp. S 83-S 84 ◽

Cited By ~ 4

Author(s):

M. Sans ◽

J. Llach ◽

J. M. Bordas ◽

V. Andreu ◽

A. Ginés ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Injection Sclerotherapy ◽

Endoscopic Injection Sclerotherapy ◽

Endoscopic Injection ◽

Unusual Form ◽

Life Threatening

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Atypical and Life-threatening Crohn’s Disease Following Colectomy: A Case Report

Wound Management & Prevention ◽

10.25270/wmp.2019.7.3640 ◽

2019 ◽

Vol 65 (07) ◽

pp. 36-40

Author(s):

Jarosław Cwaliński ◽

Jacek Hermann ◽

Tomasz Banasiewicz ◽

Jacek Paszkowski

Keyword(s):

Crohn’S Disease ◽

Case Report ◽

Crohn's Disease ◽

Life Threatening

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Crohn's disease with life-threatening hemorrhage from terminal ileum: successful control by superselective arterial embolization

Journal of Gastroenterology ◽

10.1007/s00535-005-1714-9 ◽

2005 ◽

Vol 40 (12) ◽

pp. 1155-1157 ◽

Cited By ~ 8

Author(s):

Yoshihiro Kazama ◽

Toshiaki Watanabe ◽

Masaaki Akahane ◽

Naoki Yoshioka ◽

Kuni Ohtomo ◽

...

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Terminal Ileum ◽

Arterial Embolization ◽

Life Threatening ◽

Successful Control

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Budd-Chiari syndrome: a rare and life-threatening complication of Crohn’s disease

BMJ Case Reports ◽

10.1136/bcr-2017-222946 ◽

2018 ◽

pp. bcr-2017-222946 ◽

Cited By ~ 1

Author(s):

Camila C Simoes ◽

Yezaz A Ghouri ◽

Shehzad N Merwat ◽

Heather L Stevenson

Keyword(s):

Crohn’S Disease ◽

Crohn's Disease ◽

Budd Chiari Syndrome ◽

Chiari Syndrome ◽

Life Threatening ◽

Life Threatening Complication

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Successful Drug Desensitization to Ustekinumab in a Patient with Crohn’s Disease

Case Reports in Gastroenterology ◽

10.1159/000516318 ◽

2021 ◽

pp. 657-661

Author(s):

Barrie Cohen ◽

Gitit Tomer ◽

Tatyana Gavrilova

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Case Report ◽

Crohn's Disease ◽

Multidisciplinary Approach ◽

Allergic Reactions ◽

Treatment Needs ◽

Inflammatory Conditions ◽

Life Threatening ◽

Desensitization Protocol

Ustekinumab is a monoclonal antibody used as treatment for various inflammatory conditions. We present a pediatric patient with Crohn’s disease who did not tolerate infliximab and was then changed to ustekinumab. He developed anaphylaxis to the medication after the second dose. A drug desensitization protocol was created by the allergy team leading to successful administration of both intravenous and then subcutaneous ustekinumab. As monoclonal agents become mainstays of therapy for inflammatory conditions, there are increased reports of allergic reactions. Prior reports and protocols of ustekinumab desensitization have not been reported. This case report highlights successful desensitization to ustekinumab as well as the importance of a multidisciplinary approach to addressing treatment needs of patients who develop life-threatening reactions to such medications.

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