Studies on Production of Nucleic Acid and its Related Compounds by Micro-organisms

1962 ◽  
Vol 26 (10) ◽  
pp. 648-659
Author(s):  
Michio Kojima ◽  
Yoshihisa Koaze ◽  
Takeshi Hara
1962 ◽  
Vol 26 (10) ◽  
pp. 648-654 ◽  
Author(s):  
Yujiro YAMADA ◽  
Kazumi EZAWA ◽  
Yoshihisa KOAZE ◽  
Takeshi HARA

1962 ◽  
Vol 26 (10) ◽  
pp. 655-659 ◽  
Author(s):  
Michio KOJIMA ◽  
Yoshihisa KOAZE ◽  
Takeshi HARA

1951 ◽  
Vol 189 (1) ◽  
pp. 151-157 ◽  
Author(s):  
Frederick J. Di Carlo ◽  
Alfred S. Schultz ◽  
Doris K. McManus

1983 ◽  
Vol 26 (5) ◽  
pp. 661-666 ◽  
Author(s):  
Erik De Clercq ◽  
Johan Descamps ◽  
Jan Balzarini ◽  
Jerzy Giziewicz ◽  
Philip J. Barr ◽  
...  

1973 ◽  
Vol 51 (9) ◽  
pp. 1313-1321 ◽  
Author(s):  
Morris J. Robins ◽  
James R. McCarthy Jr. ◽  
Roger A. Jones ◽  
Rudolf Mengel

Reaction of tubercidin (4-amino-7-β-D-ribofuranosylpyrrolo[2,3-d]pyrimidine) (1) with α-acetoxyisobutyryl chloride in the presence of excess sodium iodide in acetonitrile gave an acylated iodo intermediate (2) which was converted into 3′-deoxytubercidin (4) by hydrogenolysis and subsequent saponification.Analogous treatment of formycin (7-amino-3-β-D-ribofuranosylpyrazolo[4,3-d]pyrimidine) (5) gave 3′-deoxyformycin (6) and 2′-deoxyformycin (7) in an approximate ratio of 3:2. These purified nucleosides, 6 and 7 were individually deaminated enzymatically to give 3′-deoxyformycin B (8) and 2′-deoxyformycin B(9).Biological rationale, n.m.r., and mass spectra of these antibiotic-derived deoxynucleosides are discussed.


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