Effect of Some Xenobiotics on the Activities of Enzymes Relating to the Glucuronic Acid Pathway and on the Ascorbic Acid Metabolism in Guinea Pigs

1. The synthesis of l-ascorbic acid and of l-xylulose from d-glucuronolactone, d-glucuronate, l-gulonate and l-gulonolactone has been studied with liver extracts from normal and alloxan-diabetic rats. 2. In diabetic animals the synthesis of ascorbic acid is impaired, and more from glucuronolactone and glucuronate than from gulonate and gulonolactone, whereas the formation of xylulose from gulonate and gulonolactone is enhanced. These changes are reversed by insulin therapy. 3. The activity of the NAD-linked gulonate dehydrogenase is enhanced during diabetes.

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Ascorbic acid metabolism in rats and guinea pigs after the administration of ethanol

Comparative Biochemistry and Physiology Part C Pharmacology Toxicology and Endocrinology ◽

10.1016/s0742-8413(99)00054-7 ◽

1999 ◽

Vol 124 (2) ◽

pp. 175-179

Author(s):

M.V Suresh ◽

John J Lal ◽

C.V Sreeranjit kumar ◽

M Indira

Keyword(s):

Ascorbic Acid ◽

Guinea Pigs ◽

Acid Metabolism

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Glucuronic Acid Metabolism in Guinea Pigs

Acta Physiologica Scandinavica ◽

10.1111/j.1748-1716.1954.tb01137.x ◽

1954 ◽

Vol 31 (2-3) ◽

pp. 263-267 ◽

Cited By ~ 1

Author(s):

P. E. SIMOLA

Keyword(s):

Guinea Pigs ◽

Acid Metabolism ◽

Glucuronic Acid

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Nitrite effects on ascorbic acid metabolism in guinea pigs and rats

10.31274/rtd-180813-275 ◽

1978 ◽

Author(s):

Nieva T. Librojo

Keyword(s):

Ascorbic Acid ◽

Guinea Pigs ◽

Acid Metabolism

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The effect of molybdenum on ascorbic acid metabolism in rats

Biochemical Journal ◽

10.1042/bj1060633 ◽

1968 ◽

Vol 106 (3) ◽

pp. 633-637 ◽

Cited By ~ 5

Author(s):

N. Sasmal ◽

N. C. Kar ◽

Dipti Mukherjee ◽

G. C. Chatterjee

Keyword(s):

Ascorbic Acid ◽

Acid Metabolism ◽

Glucuronic Acid ◽

Liver Enzymes ◽

Marked Decrease ◽

Control Diet ◽

Ascorbic Acid Content ◽

Oxidative Breakdown ◽

Loss Of Weight

1. The effect of dietary molybdenum on the growth rate and also on ascorbic acid metabolism in rats was studied. An excess of dietary molybdenum resulted in growth retardation and loss of weight. Tolerance to molybdenum was affected by the nature of the molybdenum salt administered. 2. Molybdenum ingestion altered certain aspects of ascorbic acid metabolism in rats. The conversion of d-glucuronolactone into l-ascorbic acid in vitro and the oxidative breakdown of l-ascorbic acid by liver enzymes decreased with high molybdenum intakes. The activity of liver uronolactonase was slightly inhibited. The activities of l-gulonate dehydrogenase and l-gulonate decarboxylase were not affected appreciably. 3. Molybdenum supplementation of the control diet resulted in an increase in ascorbic acid content of spleen and adrenal gland, and in a marked decrease in the urinary excretion of ascorbic acid and glucuronic acid. The implications of these findings are discussed.

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