Model reduction of dynamic systems over a frequency interval†

1980 ◽  
Vol 31 (1) ◽  
pp. 51-62 ◽  
Author(s):  
G. LANGHOZ ◽  
Y. BISTRLTZ
Keyword(s):  
Model Reduction ◽  
Dynamic Systems ◽  
Frequency Interval

scholarly journals Metrics for regulated biochemical pathway systems

2018 ◽  
Vol 35 (12) ◽  
pp. 2118-2124 ◽  
Author(s):  
Jacob D Davis ◽  
Eberhard O Voit
Keyword(s):  
Metabolic Engineering ◽  
Network Analysis ◽  
Synthetic Biology ◽  
Model Reduction ◽  
Dynamic Systems ◽  
Biological Network ◽  
Source Code ◽  
Biochemical Pathway ◽  
Graph Metrics ◽  
Biological Network Analysis

Abstract Motivation The assessment of graphs through crisp numerical metrics has long been a hallmark of biological network analysis. However, typical graph metrics ignore regulatory signals that are crucially important for optimal pathway operation, for instance, in biochemical or metabolic studies. Here we introduce adjusted metrics that are applicable to both static networks and dynamic systems. Results The metrics permit quantitative characterizations of the importance of regulation in biochemical pathway systems, including systems designed for applications in synthetic biology or metabolic engineering. They may also become criteria for effective model reduction. Availability and implementation The source code is available at https://gitlab.com/tienbien44/metrics-bsa

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