Long-term results with lanreotide in patients with recurrent gastrointestinal angiodysplasias bleeding or obscure gastrointestinal bleeding. Benefits in efficacy and procedures consumption

The present article describes three difficult cases of recurrent bleeding from obscure causes, followed by a review of the pitfalls and pharmacological management of obscure gastrointestinal bleeding. All three patients underwent multiple investigations. An intervening complicating diagnosis or antiplatelet drugs may have compounded long-term bleeding in two of the cases. A bleeding angiodysplasia was confirmed in one case but was aggravated by the need for anticoagulation. After multiple transfusions and several attempts at endoscopic management in some cases, long-acting octreotide was associated with decreased transfusion requirements and increased hemoglobin levels in all three cases, although other factors may have contributed in some. In the third case, however, the addition of low-dose thalidomide stopped bleeding for a period of at least 23 months.

Download Full-text

W1179 Negative Capsule Endoscopy (CE) Predicts Low Rebleeding Rate and Mortality in Obscure Gastrointestinal Bleeding (OGIB): Results From Long-Term Follow-up

Gastroenterology ◽

10.1016/s0016-5085(10)63073-9 ◽

2010 ◽

Vol 138 (5) ◽

pp. S-668

Author(s):

Larry H. Lai ◽

Ronald M. Wong ◽

Kelvin K. Tsoi ◽

Jessica Ching ◽

Joseph J. Sung

Keyword(s):

Gastrointestinal Bleeding ◽

Capsule Endoscopy ◽

Obscure Gastrointestinal Bleeding ◽

Long Term Follow Up ◽

Rebleeding Rate

Download Full-text

Sa1631 Long Term Outcome of Capsule Endoscopy in Patients With Obscure Gastrointestinal Bleeding

Gastrointestinal Endoscopy ◽

10.1016/j.gie.2013.03.682 ◽

2013 ◽

Vol 77 (5) ◽

pp. AB273-AB274 ◽

Cited By ~ 2

Author(s):

Jin Su Kim ◽

Chul-Hyun Lim ◽

Jae Myung Park ◽

in Seok Lee ◽

Sang Woo Kim ◽

...

Keyword(s):

Gastrointestinal Bleeding ◽

Capsule Endoscopy ◽

Obscure Gastrointestinal Bleeding ◽

Term Outcome ◽

Long Term Outcome

Download Full-text

The Application of Hemospray in Gastrointestinal Bleeding during Emergency Endoscopy

Gastroenterology Research and Practice ◽

10.1155/2017/3083481 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 17

Author(s):

Alexander F. Hagel ◽

Heinz Albrecht ◽

Andreas Nägel ◽

Francesco Vitali ◽

Marcel Vetter ◽

...

Keyword(s):

Gastrointestinal Bleeding ◽

Salvage Therapy ◽

Previous Treatment ◽

Long Term Results ◽

Emergency Endoscopy ◽

Short Term ◽

Long Term Effect ◽

Short And Long Term ◽

Lower Endoscopy

Introduction. Gastrointestinal bleeding represents the main indication for emergency endoscopy (EE). Lately, several hemostatic powders have been released to facilitate EE.Methods. We evaluated all EE in which Hemospray was used as primary or salvage therapy, with regard to short- and long-term hemostasis and complications.Results. We conducted 677 EE in 474 patients (488 examinations in 344 patients were upper GI endoscopies). Hemospray was applied during 35 examinations in 27 patients (19 males), 33 during upper and 2 during lower endoscopy. It was used after previous treatment in 21 examinations (60%) and in 14 (40%) as salvage therapy. Short-term success was reached in 34 of 35 applications (97.1%), while long-term success occurred in 23 applications (65.7%). Similar long-term results were found after primary application (64,3%) or salvage therapy (66,7%). Rebleeding was found in malignant and extended ulcers. One major adverse event (2.8%) occurred with gastric perforation after Hemospray application.Discussion. Hemospray achieved short-term hemostasis in virtually all cases. The long-term effect is mainly determined by the type of bleeding source, but not whether it was applied as first line or salvage therapy. But, even in the failures, patients had benefit from hemodynamic stabilization and consecutive interventions in optimized conditions.

Download Full-text