Sorafenib loaded pluronic F127-lithocholic acid micelles for prostate cancer therapy: Formulation, optimization, and in vitro evaluation against LNCaP cells

2019 ◽  
Vol 69 (3) ◽  
pp. 158-172
Author(s):  
Noha Nasehi ◽  
Jaleh Varshosaz ◽  
Somayeh Taymouri ◽  
Mahboobeh Rostami ◽  
Vajihe Akbari ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Lithocholic Acid ◽  
Pluronic F127 ◽  
Lncap Cells ◽  
In Vitro Evaluation ◽  
Formulation Optimization ◽  
Prostate Cancer Therapy

scholarly journals Heavy atom-free semiconducting polymer with high singlet oxygen quantum yield for prostate cancer synergistic phototherapy

2019 ◽  
Vol 3 (6) ◽  
pp. 1123-1127 ◽  
Author(s):  
Jian Shen ◽  
Jianjiao Chen ◽  
Zhen Ke ◽  
Dengfeng Zou ◽  
Liguo Sun ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Heavy Atom ◽  
Semiconducting Polymer ◽  
Prostate Cancer Therapy

Heavy atom free NDNT have a great potential for prostate cancer therapy both in vitro and in vivo.

Synthesis and in Vitro Testing of J591 Antibody−Dendrimer Conjugates for Targeted Prostate Cancer Therapy

2004 ◽  
Vol 15 (6) ◽  
pp. 1174-1181 ◽  
Author(s):  
Anil K. Patri ◽  
Andrzej Myc ◽  
James Beals ◽  
Thommey P. Thomas ◽  
Neil H. Bander ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
In Vitro Testing ◽  
Prostate Cancer Therapy ◽  
Dendrimer Conjugates ◽  
J591 Antibody

scholarly journals Development, Characterization, and Evaluation of PSMA-Targeted Glycol Chitosan Micelles for Prostate Cancer Therapy

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Jing Xu ◽  
Jingmou Yu ◽  
Xiao Xu ◽  
Liangliang Wang ◽  
Yonghua Liu ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Therapy ◽  
Polymeric Micelles ◽  
Laser Scanning Microscopy ◽  
Critical Aggregation Concentration ◽  
Tumor Xenograft ◽  
Confocal Laser ◽  
Lncap Cells ◽  
Glycol Chitosan ◽  
Prostate Cancer Therapy

Prostate cancer-binding peptides- (PCP-) modified polymeric micelles were prepared and used for the treatment of prostate-specific membrane antigen- (PSMA-) expressing prostate cancer in a target-specific manner. Cholesterol-modified glycol chitosan (CHGC) was synthesized. PCP-conjugated CHGC (PCP-CHGC) micelles were fabricated and characterized. The degree of substitution was 5.2 PCP groups and 5.8 cholesterol groups per 100 sugar residues of glycol chitosan. The critical aggregation concentration (CAC) of PCP-CHGC copolymer was 0.0254 mg/mL. Doxorubicin (DOX) was chosen as a model antitumor drug. The DOX-loaded micelles were prepared by an o/w method. The mean diameter of DOX-loaded PCP-CHGC (DOX-PCP-CHGC) micelles was 293 nm determined by dynamic light scattering (DLS). DOX released from drug-loaded micelles was in a biphasic manner. DOX-PCP-CHGC micelles exhibited higher cytotoxicityin vitroagainst PSMA-expressing LNCaP cells than DOX-loaded CHGC (DOX-CHGC) micelles. Moreover, the cellular uptake of DOX-PCP-CHGC micelles determined by confocal laser scanning microscopy (CLSM) and flow cytometry was higher than that of DOX-CHGC micelles in LNCaP cells. Importantly, DOX-PCP-CHGC micelles demonstrated stronger antitumor efficacy against LNCaP tumor xenograft models than doxorubicin hydrochloride and DOX-CHGC micelles. Taken together, this study provides a potential way in developing PSMA-targeted drug delivery system for prostate cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document