Micellar Effects on Alkaline Hydrolysis of 3,5-Dinitro-2-chloro Benzotriflouride and 2,4-Dinitrochloro Benzene in Aqueous-Acetonitrile Mixtures

2010 ◽  
Vol 31 (12) ◽  
pp. 1752-1760 ◽  
Author(s):  
M. Sh. Ramadan ◽  
N. M. El-Mallah ◽  
S. A. Senior ◽  
G. M. Nabil ◽  
E. A. Hamed
Keyword(s):  
Alkaline Hydrolysis ◽  
Micellar Effects ◽  
Aqueous Acetonitrile ◽  
Hydrolysis Of

scholarly journals Prediction of ortho substituent effect in alkaline hydrolysis of phenyl esters of substituted benzoic acids in aqueous acetonitrile

2013 ◽  
Vol 11 (12) ◽  
pp. 1964-1975 ◽  
Author(s):  
Vilve Nummert ◽  
Mare Piirsalu ◽  
Ilmar Koppel
Keyword(s):  
Alkaline Hydrolysis ◽  
Rate Constants ◽  
Substituent Effect ◽  
Substituent Effects ◽  
Benzoic Acids ◽  
Aqueous Acetonitrile ◽  
Substituent Constants ◽  
Substituted Benzoic Acids ◽  
Hydrolysis Of ◽  
Ortho Substituent

AbstractThe second-order rate constants k for the alkaline hydrolysis of phenyl esters of meta-, para- and ortho-substituted benzoic acids, X-C6H4CO2C6H5, in aqueous 50.9% acetonitrile have been measured spectrophotometrically at 25°C. The log k values for meta and para derivatives correlated well with the Hammett σm,p substituent constants. The log k values for ortho-substituted phenyl benzoates showed good correlations with the Charton equation, containing the inductive, σI, resonance, σ○ R, and steric, E s B, and Charton υ substituent constants. For ortho derivatives the predicted (log k X)calc values were calculated with equation (log k ortho)calc = (log k H AN)exp + 0.059 + 2.19σI + 0.304σ○ R + 2.79E s B − 0.0164ΔEσI — 0.0854ΔEσ○ R, where DE is the solvent electrophilicity, ΔE = E AN — E H20 = −5.84 for aqueous 50.9% acetonitrile. The predicted (log k X)calc values for phenyl ortho-, meta- and para-substituted benzoates in aqueous 50.9% acetonitrile at 25°C precisely coincided with the experimental log k values determined in the present work.The substituent effects from the benzoyl moiety and aryl moiety were compared by correlating the log k values for the alkaline hydrolysis of phenyl esters of substituted benzoic acids, X-C6H4CO2C6H5, in various media with the corresponding log k values for substituted phenyl benzoates, C6H5CO2C6H4-X.

Micellar Effects upon the Alkaline Hydrolysis of Acetaminophen Prodrugs: Carboxylic and Carbonic Acid Esters

2014 ◽  
Vol 43 (11) ◽  
pp. 2026-2043 ◽  
Author(s):  
Fawziah F. Al-Blewi ◽  
Hamad A. Al-Lohedan ◽  
M. Z. A. Rafiquee ◽  
Zuheir A. Issa
Keyword(s):  
Alkaline Hydrolysis ◽  
Carbonic Acid ◽  
Micellar Effects ◽  
Hydrolysis Of ◽  
Acid Esters

Micellar effects upon the rate of alkaline hydrolysis of triflusal

2015 ◽  
Vol 206 ◽  
pp. 321-327 ◽  
Author(s):  
Hamad A. Al-Lohedan ◽  
Fawziah F. Al-Blewi ◽  
M.Z.A. Rafiquee ◽  
Zuheir A. Issa
Keyword(s):  
Alkaline Hydrolysis ◽  
Micellar Effects ◽  
Hydrolysis Of

Kinetics of the Micellar Effects on the Alkaline Hydrolysis of 2-Chloro-quinoxaline in Acetonitrile-Water Mixtures at 35°C

2014 ◽  
Vol 35 (4) ◽  
pp. 528-534
Author(s):  
Magda F. Fathalla ◽  
Mohamed Sh. Ramadan ◽  
Nabila M. El-Mallah ◽  
Gehan M. Nabil
Keyword(s):  
Alkaline Hydrolysis ◽  
Micellar Effects ◽  
Kinetics Of ◽  
Hydrolysis Of

Micellar effects on the alkaline hydrolysis of isatin and its derivatives

2011 ◽  
Vol 357 (2) ◽  
pp. 393-399 ◽  
Author(s):  
Abdullah S. Al-Ayed ◽  
Mohd. Sajid Ali ◽  
Hamad A. Al-Lohedan ◽  
Adel M. Al-Sulaim ◽  
Zuheir A. Issa ◽  
...  
Keyword(s):  
Alkaline Hydrolysis ◽  
Micellar Effects ◽  
Hydrolysis Of
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