scholarly journals Systematic review and meta-analysis of the epidemiology of polyautoimmunity in Sjögren’s syndrome (secondary Sjögren’s syndrome) focusing on autoimmune rheumatic diseases

2017 ◽  
Vol 47 (2) ◽  
pp. 141-154 ◽  
Author(s):  
H Alani ◽  
JR Henty ◽  
NL Thompson ◽  
E Jury ◽  
C Ciurtin
Keyword(s):  
Systematic Review ◽  
Sjögren’S Syndrome ◽  
Rheumatic Diseases ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Rheumatic Diseases ◽  
Secondary Sjögren’S Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Increased risk of thyroid disease in patients with Sjogren's syndrome: a systematic review and meta-analysis

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e6737 ◽  
Author(s):  
Xin Sun ◽  
Li Lu ◽  
Yanbin Li ◽  
Rong Yang ◽  
Ling Shan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sjögren’S Syndrome ◽  
Thyroid Disease ◽  
Fixed Effects ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Increased Risk ◽  
Sjögren‘S Syndrome

Background Sjogren’s syndrome (SS) is a chronic autoimmune epithelitis characterized by disruption of epithelial cells, ensuing lymphoplasmocytic infiltration of exocrine glands, and subsequent dryness of the mouth and eyes. Individuals with SS are more likely to have the thyroid disease. However, this association remains controversial. This meta-analysis aimed to evaluate the risk of thyroid disease in patients with SS. Methods We performed this systematic review by searching both English and Chinese literature databases. Random- or fixed-effects models were used to summarize the association between thyroid disease and SS. The results were subjected to meta-analysis with odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Results The eight articles in this meta-analysis included 988 SS cases and 2,884 controls. Overall, the risk of thyroid disease in patients with SS was significantly increased compared with controls (OR, 3.29; 95% CI [2.08–5.21]). The risk of autoimmune thyroid disease (AITD) and non-AITD were also higher in patients with SS than in controls (OR, 3.48; 95% CI [1.59–7.63]; and OR, 2.90; 95% CI [1.51–5.57], respectively). Conclusions To the best of our knowledge, this systematic review is the first to demonstrate that the risk of thyroid disease was increased in SS compared to controls, suggesting that SS patients should be screened for thyroid disease.

scholarly journals Neurological adverse events related to lip biopsy in patients suspicious for Sjögren’s syndrome: a systematic review and prevalence meta-analysis

Rheumatology ◽  
2014 ◽  
Vol 53 (7) ◽  
pp. 1208-1214 ◽  
Author(s):  
Pablo Varela Centelles ◽  
Mariña Sánchez-Sánchez ◽  
Julián Costa-Bouzas ◽  
Juan Manuel Seoane-Romero ◽  
Juan Seoane ◽  
...  
Keyword(s):  
Systematic Review ◽  
Adverse Events ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Meta Analysis ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Lip Biopsy ◽  
Sjögren‘S Syndrome

scholarly journals Autoimmune rheumatic diseases and Klinefelter syndrome Autoimunitné reumatické choroby a Klinefelterov syndróm

2016 ◽  
Vol 63 (2) ◽  
pp. 18-22 ◽  
Author(s):  
I. Lazúrová ◽  
J. Rovenský ◽  
R. Imrich ◽  
S. Blažíčková ◽  
Z. Lazúrová ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Rheumatic Diseases ◽  
Lupus Erythematosus ◽  
Sjögren's Syndrome ◽  
Klinefelter Syndrome ◽  
Connective Tissue Diseases ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Autoimmune Rheumatic Diseases ◽  
Sjögren‘S Syndrome

AbstractThe article summarizes data on the association of Klinefelter syndrome (KS) with autoimmune rheumatic diseases, that is rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), polymyositis/dermatomyositis, systemic sclerosis (SSc), mixed connective tissue diseases (MCTD), Sjogren’s syndrome and antiphospholipid syndrome (APS). Recently, a higher risk for RA, SLE and Sjogren’s syndrome in patients with KS has been clearly demonstrated. However, the association of other autoimmune rheumatic disorders such as dermatomyositis/polymyositis, SSc, MCTD and APS is reported only casually. Based on the hormonal changes in KS, there are suggestions that low androgen and higher estrogen levels might be a predisposing factor for the development of autoimmune diseases, but evidence for the association is poor. Epidemiologic studies on larger cohorts of patients are required.

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