An Association between the Natural Course of Shoulder Joint Destruction in Rheumatoid Arthritis and HLA-DRB1*0405 in Japanese Patients: SHORT REPORT

1998 ◽  
Vol 27 (2) ◽  
pp. 146-148 ◽  
Author(s):  
S. Wakitani, K. Imoto, N. Murata, H
Keyword(s):  
Rheumatoid Arthritis ◽  
Shoulder Joint ◽  
Joint Destruction ◽  
Japanese Patients ◽  
Natural Course ◽  
Short Report

scholarly journals Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose–response study of AMG 162 (Denosumab) in patients with RheumatoId arthritis on methotrexate to Validate inhibitory effect on bone Erosion (DRIVE)—a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial

2015 ◽  
Vol 75 (6) ◽  
pp. 983-990 ◽  
Author(s):  
Tsutomu Takeuchi ◽  
Yoshiya Tanaka ◽  
Naoki Ishiguro ◽  
Hisashi Yamanaka ◽  
Toshiyuki Yoneda ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Phase Ii ◽  
Bone Erosion ◽  
Therapeutic Option ◽  
Human Monoclonal Antibody ◽  
Joint Destruction ◽  
Japanese Patients ◽  
Apparent Difference ◽  
Mineral Density ◽  
Erosion Score

ObjectivesTo evaluate efficacy and safety of three different regimens of denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor kappa B (RANK) ligand (RANKL), for Japanese patients with rheumatoid arthritis (RA).MethodsIn this multicentre, randomised, placebo-controlled phase II study, 350 Japanese patients with RA between 6 months and <5 years, stratified by glucocorticoid use and rheumatoid factor status, were randomly assigned to subcutaneous injections of placebo or denosumab 60 mg every 6 months (Q6M), every 3 months (Q3M) or every 2 months (Q2M). All patients basically continued methotrexate treatment and had a supplement of calcium and vitamin D throughout the study. The primary endpoint was change in the modified Sharp erosion score from baseline to 12 months.ResultsDenosumab significantly inhibited the progression of bone erosion at 12 months compared with the placebo, and the mean changes of the modified Sharp erosion score at 12 months from baseline were 0.99, 0.27 (compared with placebo, p=0.0082), 0.14 (p=0.0036) and 0.09 (p<0.0001) in the placebo, Q6M, Q3M and Q2M, respectively. Secondary endpoint analysis revealed that denosumab also significantly inhibited the increase of the modified total Sharp score compared with the placebo, with no obvious evidence of an effect on joint space narrowing for denosumab. As shown in previous studies, denosumab increased bone mineral density. No apparent difference was observed in the safety profiles of denosumab and placebo.ConclusionsAddition of denosumab to methotrexate has potential as a new therapeutic option for patients with RA with risk factors of joint destruction.Trial registration numberJapicCTI-101263.

Suppression of joint destruction with subcutaneous tocilizumab for Japanese patients with rheumatoid arthritis in clinical practice

2019 ◽  
Vol 30 (5) ◽  
pp. 807-815
Author(s):  
Yasuharu Nakashima ◽  
Masakazu Kondo ◽  
Eisuke Shono ◽  
Takashi Ishinishi ◽  
Hiroshi Tsukamoto ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Practice ◽  
Joint Destruction ◽  
Japanese Patients

Natural course of joint destruction and fluctuation of serum c1q levels in patients with rheumatoid arthritis

1988 ◽  
Vol 31 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Takahiro Ochi ◽  
Rokuro Iwase ◽  
Kunio Yonemasu ◽  
Mitsuhiro Matsukawa ◽  
Minoru Yoneda ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Destruction ◽  
Natural Course

Knee and/or hip joint destruction in rheumatoid arthritis is associated with HLA-DRB1*0405 in Japanese patients

1998 ◽  
Vol 17 (6) ◽  
pp. 485-488 ◽  
Author(s):  
S. Wakitani ◽  
K. Kuwata ◽  
K. Imoto ◽  
N. Murata ◽  
H. Oonishi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Hip Joint ◽  
Joint Destruction ◽  
Japanese Patients

Lack of association betweenIL-15genetic variants and progression of joint destruction in Japanese patients with rheumatoid arthritis

2013 ◽  
Vol 73 (4) ◽  
pp. 784-785 ◽  
Author(s):  
Shinji Yoshida ◽  
Katsunori Ikari ◽  
Koichiro Yano ◽  
Yoshiaki Toyama ◽  
Atsuo Taniguchi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Destruction ◽  
Japanese Patients

Predictive factors related to shoulder joint destruction in rheumatoid arthritis patients treated with biologics: A prospective study

2016 ◽  
Vol 27 (4) ◽  
pp. 587-592 ◽  
Author(s):  
Yukio Yonemoto ◽  
Koichi Okamura ◽  
Tsutomu Kobayashi ◽  
Tetsuya Kaneko ◽  
Chisa Okura ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Prospective Study ◽  
Predictive Factors ◽  
Shoulder Joint ◽  
Joint Destruction ◽  
A Prospective Study

Immunoregulatory Role of Interleukin-37 in Rheumatoid Arthritis; Relation to Disease Activity and Joint Destruction

2018 ◽  
Vol 86 (September) ◽  
pp. 3341-3348
Author(s):  
DALIA B. EL-BOHOTY, M.Sc.; DOAA S. AL-ASHKAR, M.D. ◽  
MAALY M. MABROUK, M.D.; HALA M. NAGY, M.D.
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Joint Destruction
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