Molecular interaction of anti-cancer ligands with human brain acetylcholinesterase

2020 ◽  
pp. 1-10
Author(s):  
Shazi Shakil
Keyword(s):  
Human Brain ◽  
Molecular Interaction ◽  
Anti Cancer ◽  
Brain Acetylcholinesterase

Molecular Interaction of the Antineoplastic Drug, Methotrexate with Human Brain Acetylcholinesterase: A Docking Study

2012 ◽  
Vol 11 (2) ◽  
pp. 142-147 ◽  
Author(s):  
Shazi Shakil ◽  
Mohammad A. Kamal ◽  
Shams Tabrez ◽  
Adel M. Abuzenadah ◽  
Adeel G.A. Chaudhary ◽  
...  
Keyword(s):  
Human Brain ◽  
Molecular Interaction ◽  
Docking Study ◽  
Antineoplastic Drug ◽  
Brain Acetylcholinesterase

Molecular Interaction of Human Brain Acetylcholinesterase with a Natural Inhibitor Huperzine-B: An Enzoinformatics Approach

2014 ◽  
Vol 13 (3) ◽  
pp. 487-490 ◽  
Author(s):  
Aftab Alam ◽  
Sibhghatulla Shaikh ◽  
Syed Ahmad ◽  
Mohammad Ansari ◽  
Shahnawaz Shakil ◽  
...  
Keyword(s):  
Human Brain ◽  
Molecular Interaction ◽  
Natural Inhibitor ◽  
Brain Acetylcholinesterase

scholarly journals Interaction of Human Brain Acetylcholinesterase with Cyclophosphamide: A Molecular Modeling and Docking Study

2011 ◽  
Vol 10 (7) ◽  
pp. 845-848 ◽  
Author(s):  
Shazi Shakil ◽  
Rosina Khan ◽  
Shams Tabrez ◽  
Qamre Alam ◽  
Nasimudeen R. Jabir ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Human Brain ◽  
Docking Study ◽  
Molecular Modeling And Docking ◽  
Brain Acetylcholinesterase

scholarly journals Monoclonal antibodies against a C-terminal peptide of human brain acetylcholinesterase distinguish between erythrocyte and brain acetylcholinesterases

1996 ◽  
Vol 42 (1) ◽  
pp. 19-23 ◽  
Author(s):  
N Boschetti ◽  
U Brodbeck ◽  
S P Jensen ◽  
C Koch ◽  
B Nørgaard-Pedersen
Keyword(s):  
Monoclonal Antibodies ◽  
Human Brain ◽  
Solid Phase ◽  
Bovine Brain ◽  
Mammalian Brain ◽  
Dot Blot ◽  
Electric Eel ◽  
Terminal Amino ◽  
Dot Blot Analysis ◽  
Brain Acetylcholinesterase

Abstract Monoclonal antibodies (mAbs) were raised against a peptide of the 10 C-terminal amino acids of human brain acetylcholinesterase (AChE): H-Tyr-Ser-Lys-Gln-Asp-Arg-Cys-Ser-Asp-Leu-OH. Two positive clones (mAbs 190-1 and 190-2) were selected and tested for their ability to distinguish between mammalian brain and erythrocyte AChEs. In a solid-phase enzyme antigen immunoassay as well as by Western- and dot-blot analysis, both antibodies showed clear binding to AChE from human and bovine brain but not to AChE from erythrocytes. MAbs 190-1 and 190-2 reacted with neither AChE from electric eel nor butyrylcholinesterase from human serum. Both antibodies were used in a quantitative assay for AChE in amniotic fluids, where AChE activity could be found only in samples from open neural tube-defect pregnancies, but not in fluids from normal pregnancies or in artificially blood-contaminated samples.

Specific oligobodies against human brain acetylcholinesterase

2003 ◽  
Vol 989 (2) ◽  
pp. 147-151
Author(s):  
Xing-Mei Zhang ◽  
Qian Li ◽  
Yu-Sheng Shi ◽  
Jun-Hua Wu ◽  
Ning-Sheng Shao ◽  
...  
Keyword(s):  
Human Brain ◽  
Brain Acetylcholinesterase
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