Inhibitory effect of aqueous extracts of some herbs on human platelet aggregation in vitro

Platelets ◽  
2005 ◽  
Vol 16 (8) ◽  
pp. 469-473 ◽  
Author(s):  
Saulnier Pierre ◽  
Lynn Crosbie ◽  
Asim K. Duttaroy
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Inhibitory Effect ◽  
Aqueous Extracts ◽  
Human Platelet Aggregation

Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro

2014 ◽  
Vol 21 (4) ◽  
pp. 286-290 ◽  
Author(s):  
Ling-geng Yan ◽  
Jun-shan Ruan ◽  
Lei Zhang ◽  
Fang-tian Fan ◽  
Feng Zhang ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Aqueous Extracts ◽  
Human Platelet Aggregation

Inhibitory Effect of Staphylokinase on Platelet Aggregation

1993 ◽  
Vol 70 (05) ◽  
pp. 834-837 ◽  
Author(s):  
Akira Suehiro ◽  
Yoshio Oura ◽  
Motoo Ueda ◽  
Eizo Kakishita
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Degradation Products ◽  
Platelet Rich Plasma ◽  
Inhibitory Effect ◽  
Effective Concentration ◽  
Inhibit Platelet Aggregation ◽  
Platelet Suspension ◽  
Washed Platelet ◽  
Human Platelet Aggregation

SummaryWe investigated the effect of staphylokinase (SAK), which has specific thrombolytic properties, on human platelet aggregation. Platelet aggregation induced with collagen was observed following preincubation of platelets in platelet-rich plasma (PRP) or washed platelet suspension (WP) with SAK at 37° C for 30 min. SAK inhibited platelet aggregation in PRP only at the highest examined concentration (1 x 10-4 g/ml). Although SAK did not inhibit platelet aggregation in WP which contained fibrinogen, it did when the platelets had been preincubated with SAK and plasminogen. The most effective concentration in WP was 1 x 10-6 g/ml. The effect could be inhibited by adding aprotinin or α2-antiplasmin. The highest generation of plasmin in the same preincubation fluid was detected at 1 x 10-6 g/ml SAK. We concluded that SAK can inhibit platelet aggregation in WP by generating plasmin and/or fibrinogen degradation products, but is only partially effective in PRP because of the existence of α2-antiplasmin.

Heparin Counteracts the Antiaggregating Effect of Prostacyclin by Potentiating Platelet Aggregation

1983 ◽  
Vol 49 (02) ◽  
pp. 081-083 ◽  
Author(s):  
Vittorio Bertelé ◽  
Maria Carla Roncaglioni ◽  
Maria Benedetta Donati ◽  
Giovanni de Gaetano
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Specific Interaction ◽  
Inhibitory Effect ◽  
Effective Inhibitor ◽  
Inhibitory Potency ◽  
Human Platelet Aggregation

SummaryIt has recently been reported that heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on human platelet aggregation. The mechanism of this interaction has not yet been unequivocally established. We present here evidence that heparin (Liquemin Roche) does not react directly with PGI2 but counteracts its inhibitory effect by potentiating platelet aggregation. In the absence of heparin, PGI2 was a less effective inhibitor of platelet aggregation induced by the combination of ADP and serotonin than by ADP alone. Moreover, the inhibitory effect of PGI2 was similarly reduced when increasing the concentrations of ADP (in the absence of heparin). The lack of a specific interaction between heparin and PGI2 is supported by the observation that, in the presence of heparin, other prostaglandins such as PGD2 and PGE1, and a non-prostanoid compound such as adenosine also appeared to lose their inhibitory potency. It is concluded that heparin opposes platelet aggregation inhibitory effect of PGI2 by enhancement of platelet aggregation.

In Vitro Assay of Quinoa (Chenopodium quinoa Willd.) and Lupin (Lupinus spp.) Extracts on Human Platelet Aggregation

2020 ◽  
Vol 75 (2) ◽  
pp. 215-222
Author(s):  
Marcelo Alarcón ◽  
Michelle Bustos ◽  
Diego Mendez ◽  
Eduardo Fuentes ◽  
Ivan Palomo ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Chenopodium Quinoa ◽  
In Vitro Assay ◽  
Vitro Assay ◽  
Human Platelet Aggregation

scholarly journals Inhaled Nitric Oxide Inhibits Human Platelet Aggregation, P-Selectin Expression, and Fibrinogen Binding In Vitro and In Vivo

Circulation ◽  
1998 ◽  
Vol 97 (15) ◽  
pp. 1481-1487 ◽  
Author(s):  
André Gries ◽  
Christoph Bode ◽  
Karlheinz Peter ◽  
Axel Herr ◽  
Hubert Böhrer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Platelet Aggregation ◽  
Human Platelet ◽  
Inhaled Nitric Oxide ◽  
Human Platelet Aggregation ◽  
Fibrinogen Binding

In vitro and ex vivo effect of cimetidine on human platelet aggregation

1986 ◽  
Vol 42 (1) ◽  
pp. 113-114
Author(s):  
B. Gachályi ◽  
K. Tihanyi ◽  
Á. Vas ◽  
B. Nádas ◽  
A. Káldor
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Ex Vivo ◽  
Human Platelet Aggregation

In vitro enhancement of human platelet aggregation by somatostatin

1988 ◽  
Vol 44 (10) ◽  
pp. 892-894 ◽  
Author(s):  
P. P. Gazzaniga ◽  
G. Di Macco ◽  
R. La Mancusa ◽  
A. Oddi ◽  
G. Pappalardo ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation

Dehydroepiandrosterone Inhibits Human Platelet Aggregation in Vitro and in Vivoa

2006 ◽  
Vol 774 (1) ◽  
pp. 281-290 ◽  
Author(s):  
ROBERT L. JESSE ◽  
KATHY LOESSER ◽  
DAVID M. EICH ◽  
YONG ZHEN QIAN ◽  
MICHAEL L. HESS ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation

2,3,5,4’-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) attenuates human platelet aggregation, secretion and spreading in vitro

2014 ◽  
Vol 133 (2) ◽  
pp. 211-217 ◽  
Author(s):  
Ke Xiang ◽  
Gang Liu ◽  
Ya-Jun Zhou ◽  
Hong-Zhen Hao ◽  
Zhao Yin ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Human Platelet Aggregation
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