No association between p53 status and alpha-particle-induced chromosomal instability in human lymphoblastoid cells

1996 ◽  
Vol 69 (2) ◽  
pp. 167-174 ◽  
Author(s):  
M. A. KADHIM
Keyword(s):  
Alpha Particle ◽  
Chromosomal Instability ◽  
Lymphoblastoid Cells ◽  
P53 Status

The role of nucleophosmin/B23 in radiation-induced chromosomal instability in human lymphoblastoid cells of different p53 genotypes

2010 ◽  
Vol 86 (12) ◽  
pp. 1031-1043 ◽  
Author(s):  
Honghong Chen ◽  
Rongfei Jia ◽  
Meijun Zhou ◽  
Aihong Xu ◽  
Yuxing Hu ◽  
...  
Keyword(s):  
Chromosomal Instability ◽  
Lymphoblastoid Cells ◽  
Radiation Induced

(Z)-3,5,4′-Tri-O-methyl-resveratrol, induces apoptosis in human lymphoblastoid cells independently of their p53 status

2004 ◽  
Vol 211 (2) ◽  
pp. 155-161 ◽  
Author(s):  
Yann Schneider ◽  
Barbara Fischer ◽  
David Coelho ◽  
Stamatiki Roussi ◽  
Francine Gosse ◽  
...  
Keyword(s):  
Lymphoblastoid Cells ◽  
P53 Status

A Tale of Two Colons and Two Cancers

Swiss Surgery ◽  
2003 ◽  
Vol 9 (1) ◽  
pp. 3-7 ◽  
Author(s):  
Gervaz ◽  
Bühler ◽  
Scheiwiller ◽  
Morel
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Adjuvant Chemotherapy ◽  
Splenic Flexure ◽  
Chromosomal Instability ◽  
Proximal Colon ◽  
Colorectal Carcinogenesis ◽  
Physiological Data ◽  
Central Hypothesis ◽  
Group Stratification

The central hypothesis explored in this paper is that colorectal cancer (CRC) is a heterogeneous disease. The initial clue to this heterogeneity was provided by genetic findings; however, embryological and physiological data had previously been gathered, showing that proximal (in relation to the splenic flexure) and distal parts of the colon represent distinct entities. Molecular biologists have identified two distinct pathways, microsatellite instability (MSI) and chromosomal instability (CIN), which are involved in CRC progression. In summary, there may be not one, but two colons and two types of colorectal carcinogenesis, with distinct clinical outcome. The implications for the clinicians are two-folds; 1) tumors originating from the proximal colon have a better prognosis due to a high percentage of MSI-positive lesions; and 2) location of the neoplasm in reference to the splenic flexure should be documented before group stratification in future trials of adjuvant chemotherapy in patients with stage II and III colon cancer.

ALPHA-PARTICLE RESONANT STATES IN MEDIUM WEIGHT NUCLEI

1971 ◽  
Vol 32 (C6) ◽  
pp. C6-185-C6-187
Author(s):  
A. DUDEK ◽  
P. E. HODGSON
Keyword(s):  
Alpha Particle ◽  
Resonant States ◽  
Medium Weight
Sign in / Sign up

Export Citation Format

Share Document