Chemical and Antimicrobial Studies ofJuniperus SabinaL. andJuniperus foetidissimaWilld. Essential Oils

Abstract Background Nanobiomedicines have gained increasing attention for their potential to improve efficacy and are emerging as a promising therapeutic paradigm. Magnetic nanoconjugates loaded with bioactive drugs have the advantage of sustained circulation in the bloodstream and significantly reduced toxicity of therapeutic agents in a precise manner. The well-developed surface chemistry of Fe3O4 has led to the development better tools, promoting them as nanoplatforms with potential technological applications in biomedical sciences. Results Fe3O4 phytohybrids with Laxmitaru extract as the primary coating and loaded with Eugenol and Ylang-Ylang essential oils were successfully synthesized. The X-ray diffraction technique has revealed the high purity nanoparticle materials, as no additional impurity peaks were observed. Fourier transform infra-red spectra have confirmed the presence of a primary coating of Laxmitaru extract and a secondary layer of essential oil, as additional peaks and broadening are observed in drug-loaded Fe3O4 nanoparticles. Magnetic susceptibility values indicate the material's superparamagnetic nature. Transmission electron microscopy images have ensured that the particles were spherical, monodispersed, and in the range of 4.30 nm to 13.98 nm. Antimicrobial studies show inhibition zones on the microorganisms S. Aureus and E. Coli with enhanced activity. Drug entrapment efficiency studies revealed the encapsulation of drug molecules onto Fe3O4-Laxmitaru composite. Dynamic light scattering studies confirm the increase in hydrodynamic size, indicating the loading of essential oils and the decrease in polydispersity index ensures monodispersed nanoparticles. The antioxidant study showed the essential oils retained their antioxidant activity even after they were conjugated on Fe3O4-Lax composites. Conclusions Laxmitaru phytochemical-coated Fe3O4 nanoparticles were successfully conjugated with Eugenol and Ylang-Ylang essential oils. Our results provide a model therapeutic approach for the development of new alternative strategies for enhancing antimicrobial and antioxidant therapy, with potential advantages in the field of nanobiomedicine.

Download Full-text

Chemical Composition and Antimicrobial Studies of the Essential Oils of Jatropha integerrima Jacq (Leaf and Seeds)

Natural Product Communications ◽

10.1177/1934578x0700200813 ◽

2007 ◽

Vol 2 (8) ◽

pp. 1934578X0700200

Author(s):

Adeolu O. Eshilokun ◽

Adeleke A. Kasali ◽

Isiaka A. Ogunwande ◽

Tameka M. Walker ◽

Williams N. Setzer

Keyword(s):

Staphylococcus Aureus ◽

Antimicrobial Activity ◽

Chemical Composition ◽

Essential Oils ◽

Significant Variation ◽

Seed Oil ◽

Chemical Constituents ◽

The Other ◽

Antimicrobial Studies ◽

And Staphylococcus Aureus

The chemical composition of the essential oils of the leaves and seeds of Jatropha integerrima was investigated by GC and GC-MS. The results showed significant variation in the chemical constituents of the tissue/parts analyzed. The leaf has pentadecanal (32.4%), 1,8-cineole (11.2%) and β-ionone (10.8%) as the major components. On the other hand, the seed oil is comprised mainly of aliphatic hydrocarbons represented by pentacosane (13.6%), hexacosane (13.3%), octacosane (12.3%) and heptacosane (10.1%). However, the defatted seed oil was predominantly made up of the monoterpenes 1,8-cineole (35.5%), p-cymene (20.5%) and α-pinene (16.5%). The oils displayed weak antimicrobial activity against Bacillus cereus and Staphylococcus aureus.

Download Full-text