TTS, namely text-to-speech, is a kind of technology who can convert text information into sound signal according to information Speech processing rules. TTS, as the synthetic technology of the pronunciation, is the key technology in the current development of computer technology, and one of the most forward technical in its voice service, telephone banking, and information home appliances, mobile PDA fields. TTS has its extensive applications. In this paper, TTS is applied to electronic speech reader, which changes traditional way to read e-book, and both listening to and novels and learning English. This article introduces a method about how to make use of TTS technology, and how to achieve an electronic Speech reader of programming based on Visual Studio C# 2008 environment bring API and Microsoft SAPI interface.