close proximity
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2022 ◽  
Vol 8 ◽  
Ali Jalali ◽  
Justin D. Bell ◽  
Harry K. Gorfine ◽  
Simon Conron ◽  
Khageswor Giri

Recreational fishing is a popular pastime and multibillion dollar industry in Australia, playing a key economic role, especially in regional areas. In the State of Victoria, Port Phillip Bay (PPB), bordered by Melbourne and its suburbs, is the largest of the State’s marine recreational fisheries. At present, little is known about the spatial and temporal dimensions of angler travel from origins to destinations, and the applicability of such spatial knowledge in fisheries management. To address this lack of information we assessed spatiotemporal dynamics and patterns in fishing trips, based upon travel distances on land and water, to acquire insight into the spatial ranges over which anglers residing in various locations travel to fishing destinations in the environs of PPB. Data for each angler per fishing trip, from 6,035 boat-based creel surveys, collected at 20 boat ramps in PPB during a 10-year period from 2010 to 2019, were analyzed by applying geospatial modeling. Differences were observed in both land and water travel distance by region and popular target species, with anglers who launched from Bellarine region traveling further on land, and those who targeted snapper traveling further on water. It was also evident that most anglers resided within close proximity of PPB, often less than 50 km, although some anglers traveled long distances across the State to access fishing locations, particularly when targeting snapper. This work further highlights the importance of spatially explicit approaches to inform fisheries management by identifying users across different landscape and seascape scales, and out-of-region or State fishing trips, which may especially impact coastal communities and benefit local businesses.

2022 ◽  
Evianne Rovers ◽  
Matthieu Schapira

Proximity pharmacology (ProxPharm) is a novel paradigm in drug discovery where a small molecule brings two proteins in close proximity to elicit a signal, generally from one protein onto another. The potential of ProxPharm compounds as a new therapeutic modality is firmly established by proteolysis targeting chimeras (PROTACs) that bring an E3 ubiquitin ligase in proximity to a target protein to induce ubiquitination and subsequent degradation of the target protein. The concept can be expanded to induce other post-translational modifications via the recruitment of different types of protein-modifying enzymes. To survey the human proteome for opportunities in proximity pharmacology, we systematically mapped non-catalytic drug binding pockets on the structure of protein-modifying enzymes available from the Protein Databank. In addition to binding sites exploited by previously reported ProxPharm compounds, we identified putative ligandable non-catalytic pockets in 188 kinases, 42 phosphatases, 26 deubiquitinases, 9 methyltransferases, 7 acetyltransferases, 7 glycosyltransferases, 4 deacetylases, 3 demethylases and 2 glycosidases, including cavities occupied by chemical matter that may serve as starting points for future ProxPharm compounds. This systematic survey confirms that proximity pharmacology is a versatile modality with largely unexplored and promising potential, and reveals novel opportunities to pharmacologically rewire molecular circuitries.

2022 ◽  
Vol 63 (1) ◽  
pp. 20
Omer Trivizki ◽  
Eric M. Moult ◽  
Liang Wang ◽  
Prashanth Iyer ◽  
Yingying Shi ◽  

Processes ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 163
Vitali Vasil’evich Starkov ◽  
Ekaterina Alexanrovna Gosteva ◽  
Dmitry Dmitry Zherebtsov ◽  
Maxim Vladimirovich Chichkov ◽  
Nikita Valerievich Alexandrov

This review presents the results of the local formation of nanostructured porous silicon (NPSi) on the surface of silicon wafers by anodic etching using a durite intermediate ring. The morphological and crystallographic features of NPSi structures formed on n- and p-type silicon with low and relatively high resistivity have also been investigated. The proposed scheme allows one to experiment with biological objects (for example, stem cells, neurons, and other objects) in a locally formed porous structure located in close proximity to the electronic periphery of sensor devices on a silicon wafer.

2022 ◽  
Li‐Li Ling ◽  
Weijie Yang ◽  
Peng Yan ◽  
Min Wang ◽  
Hai‐Long Jiang

2022 ◽  
Shan Qi ◽  
Javier Mota ◽  
Siu-Hong Chan ◽  
Johanna Villarreal ◽  
Nan Dai ◽  

Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from S-adenosyl-L-methionine to N6 amino group of adenosine bases in RNA (m6A) and DNA (m6dA). Emerging evidence highlights a role of METTL3-METTL14 in the chromatin context, especially in processes where DNA and RNA are held in close proximity. However, a mechanistic framework about specificity for substrate RNA/DNA and their interrelationship remain unclear. By systematically studying methylation activity and binding affinity to a number of DNA and RNA oligos with different propensities to form inter- or intra-molecular duplexes or single-stranded molecules in vitro, we uncover an inverse relationship for substrate binding and methylation and show that METTL3-METTL14 preferentially catalyzes the formation of m6dA in single-stranded DNA (ssDNA), despite weaker binding affinity to DNA. In contrast, it binds structured RNAs with high affinity, but methylates the target adenosine in RNA (m6A) much less efficiently than it does in ssDNA. We also show that METTL3-METTL14-mediated methylation of DNA is largely restricted by structured RNA elements prevalent in long noncoding and other cellular RNAs.

Nanophotonics ◽  
2022 ◽  
Vol 0 (0) ◽  
Sergey G. Menabde ◽  
Jacob T. Heiden ◽  
Joel D. Cox ◽  
N. Asger Mortensen ◽  
Min Seok Jang

Abstract Polaritonic modes in low-dimensional materials enable strong light–matter interactions and the manipulation of light on nanometer length scales. Very recently, a new class of polaritons has attracted considerable interest in nanophotonics: image polaritons in van der Waals crystals, manifesting when a polaritonic material is in close proximity to a highly conductive metal, so that the polaritonic mode couples with its mirror image. Image modes constitute an appealing nanophotonic platform, providing an unparalleled degree of optical field compression into nanometric volumes while exhibiting lower normalized propagation loss compared to conventional polariton modes in van der Waals crystals on nonmetallic substrates. Moreover, the ultra-compressed image modes provide access to the nonlocal regime of light–matter interaction. In this review, we systematically overview the young, yet rapidly growing, field of image polaritons. More specifically, we discuss the dispersion properties of image modes, showcase the diversity of the available polaritons in various van der Waals materials, and highlight experimental breakthroughs owing to the unique properties of image polaritons.

2022 ◽  
Leilah K. McCarthy ◽  
Coralie D. Adam ◽  
Jason M. Leonard ◽  
Peter G. Antresian ◽  
Derek Nelson ◽  

Biology ◽  
2022 ◽  
Vol 11 (1) ◽  
pp. 68
Min-Jee Kim ◽  
Jeong-Sun Park ◽  
Hyeongmin Kim ◽  
Seong-Ryul Kim ◽  
Seong-Wan Kim ◽  

We report 37 mitochondrial genome (mitogenome) sequences of Bombyx mori strains (Lepidoptera: Bombycidae) and four of B. mandarina individuals, each preserved and collected, respectively, in South Korea. These mitogenome sequences combined with 45 public data showed a substantial genetic reduction in B. mori strains compared to the presumed ancestor B. mandarina, with the highest diversity detected in the Chinese origin B. mori. Chinese B. mandarina were divided into northern and southern groups, concordant to the Qinling–Huaihe line, and the northern group was placed as an immediate progenitor of monophyletic B. mori strains in phylogenetic analyses, as has previously been detected. However, one individual that was in close proximity to the south Qinling–Huaihe line was exceptional, belonging to the northern group. The enigmatic South Korean population of B. mandarina, which has often been regarded as a closer genetic group to Japan, was most similar to the northern Chinese group, evidencing substantial gene flow between the two regions. Although a substantial genetic divergence is present between B. mandarina in southern China and Japan, a highly supported sister relationship between the two regional populations may suggest the potential origin of Japanese B. mandarina from southern China instead of the Korean peninsula.

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