A pH-Sensitive Hydrogel with Hydrophobic Association for Controlled Release of Poorly Water-Soluble Drugs

2009 ◽  
Vol 46 (8) ◽  
pp. 816-820 ◽  
Author(s):  
Jing Ma ◽  
Xinxing Liu ◽  
Zhiwen Yang ◽  
Zhen Tong
Keyword(s):  
Controlled Release ◽  
Ph Sensitive ◽  
Water Soluble ◽  
Hydrophobic Association ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Ph Sensitive Hydrogel

pH-Sensitive Micelles Self-Assembled from Amphiphilic Copolymer Brush for Delivery of Poorly Water-Soluble Drugs

2011 ◽  
Vol 12 (1) ◽  
pp. 116-122 ◽  
Author(s):  
You Qiang Yang ◽  
Ling Shan Zheng ◽  
Xin Dong Guo ◽  
Yu Qian ◽  
Li Juan Zhang
Keyword(s):  
Ph Sensitive ◽  
Amphiphilic Copolymer ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble ◽  
Self Assembled ◽  
Copolymer Brush

scholarly journals Cyclodextrin Controlled Release of Poorly Water-Soluble Drugs from Hydrogels

Drug Delivery ◽  
2008 ◽  
Vol 15 (1) ◽  
pp. 69-80 ◽  
Author(s):  
Henriette Sie Woldum ◽  
Kim Lambertsen Larsen ◽  
Flemming Madsen
Keyword(s):  
Controlled Release ◽  
Water Soluble ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

scholarly journals Electrospun Janus zein–PVP nanofibers provide a two-stage controlled release of poorly water-soluble drugs

2020 ◽  
Vol 196 ◽  
pp. 109075 ◽  
Author(s):  
Monglong Wang ◽  
Ding Li ◽  
Jie Li ◽  
Siyu Li ◽  
Zhuo Chen ◽  
...  
Keyword(s):  
Controlled Release ◽  
Water Soluble ◽  
Two Stage ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

Fast-dissolving Solid Dispersions for the Controlled Release of Poorly Water-soluble Drugs

2020 ◽  
Vol 26 ◽  
Author(s):  
Phuong H.L. Tran ◽  
Beom-Jin Lee ◽  
Thao T.D. Tran
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Oral Drug Delivery ◽  
Solid Dispersions ◽  
Water Soluble ◽  
Drug Dissolution ◽  
Oral Drug ◽  
Poorly Water Soluble Drugs ◽  
Water Soluble Drugs ◽  
Poorly Water Soluble

: Solid dispersions offer many advantages for oral drug delivery of poorly water-soluble drugs over other systems, including an increase in drug solubility and drug dissolution. The improvement of drug absorption and higher bioavailability of active pharmaceutical ingredients in the gastrointestinal tract have been reported in various studies. In certain circumstances, a rapid pharmacological effect is required for patients. Fast-dissolving solid dispersions provide an ideal formulation in such cases. This report will provide an overview of current studies on fast-dissolving solid dispersions, including not only solid dispersion powders with fast dissolution rates but also specific does forms for the controlled release of poorly water-soluble drugs. Specifically, the applications of fast-dissolving solid dispersions will be described in every specific case. Moreover, pharmaceutical approaches and the utilization of polymers will be summarized. The classification and analysis of fast-dissolving solid dispersions could provide insight into strategies and potential applications in future drug delivery developments.

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