Water soluble calix[4]arenes. A thermodynamic investigation of proton complex formation

1992 ◽  
Vol 1 (1) ◽  
pp. 19-24 ◽  
Author(s):  
Giuseppe Arena ◽  
Rosario Cali ◽  
Gaetano Giuseppe Lombardo ◽  
Enrico Rizzarelli ◽  
Domenico Sciotto ◽  
...  
Keyword(s):  
Complex Formation ◽  
Water Soluble ◽  
Thermodynamic Investigation

Alkalinizing Water-Soluble Local Anesthetic Solutions by Addition of Cyclodextrin

1998 ◽  
Vol 23 (2) ◽  
pp. 176-181 ◽  
Author(s):  
Michio Miyoshi ◽  
Toshiaki Imoto ◽  
Yasutake Hiji
Keyword(s):  
Complex Formation ◽  
Inclusion Complex ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Water Soluble ◽  
Spectral Change ◽  
Practical Application ◽  
Inclusion Complex Formation ◽  
Physiologic Saline ◽  
Form Inclusion Complex

Background and objectivesThe use of sodium bicarbonate for alkalinization of local anesthetics to improve their efficacy has some disadvantages including decreased stability of the solutions. The present study was performed to evaluate usefulness of cyclodextrins (CDs) in improving the solubility and stability of local anesthetic solutions at near physiologic pH without precipitation.MethodsSolubility of local anesthetics with or without CDs in physiologic saline was investigated by monitoring cloudiness or precipitate formation visually and by recording absorbance at 620 nm. Interaction of anesthetic and CD was also studied spectrophotometrically using spectral change of the drugs associated with the inclusion complex formation.ResultsCyclodextrins improved the solubility and stability of the four local anesthetics studied (dibucaine, tetracaine, bupivacaine, and lidocaine). In the neutral pH region, the effects of the CDs were more significant with dibucaine and tetracaine, which are more hydrophobic than the other two. A type of effective CD was different for each anesthetic depending partly on the tendency to form inclusion complex with local anesthetic. The local anesthetic solutions solubilized by CDs were found to remain clear for more than 72 hours without any visible precipitation or turbidity at neutral pHs.ConclusionsThe improved solubility of local anesthetics by adding CD may be caused by inclusion complex formation of CD with local anesthetics. This new preparation for the alkalinized water-soluble anesthetic solutions may be useful for practical application in the clinical setting, although this awaits further study.

scholarly journals Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers

2011 ◽  
Vol 54 (5) ◽  
pp. 965-972 ◽  
Author(s):  
Leticia Norma Carpentieri Rodrigues ◽  
Michelle Georges Issa ◽  
Ana Carolina Cavassin Asbahr ◽  
Marco Aurélio Carvalho Silva ◽  
Humberto Gomes Ferraz
Keyword(s):  
Complex Formation ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers ◽  
Multicomponent Complex

Water Soluble Complexes of the Antiviral Drugs, 9-[(1,3-Dihydroxy-2-propoxy)Methyl]guanine and Acyclovir: The Role of Hydrophobicity in Complex Formation

1986 ◽  
Vol 75 (7) ◽  
pp. 648-653 ◽  
Author(s):  
Richard A. Kenley ◽  
Stuart E. Jackson ◽  
John S. Winterle ◽  
Yelena Shunko ◽  
Gary C. Visor
Keyword(s):  
Complex Formation ◽  
Antiviral Drugs ◽  
Water Soluble ◽  
Soluble Complexes

Complex formation analysis of water-soluble calixarenes by capillary zone electrophoresis

2001 ◽  
Vol 934 (1-2) ◽  
pp. 113-122 ◽  
Author(s):  
Koji Oshita ◽  
Toshio Takayanagi ◽  
Mitsuko Oshima ◽  
Shoji Motomizu
Keyword(s):  
Complex Formation ◽  
Capillary Zone Electrophoresis ◽  
Water Soluble ◽  
Zone Electrophoresis ◽  
Capillary Zone

Complex Formation of β-Cyclodextrin- and Perfluorocarbon-Modified Water-Soluble Polymers

Langmuir ◽  
1998 ◽  
Vol 14 (18) ◽  
pp. 4972-4977 ◽  
Author(s):  
Huashi Zhang ◽  
Thieo E. Hogen-Esch ◽  
Frédéric Boschet ◽  
André Margaillan
Keyword(s):  
Complex Formation ◽  
Water Soluble ◽  
Water Soluble Polymers ◽  
Soluble Polymers
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