Effects of tricalcium phosphate in polycaprolactone scaffold for mesenchymal stem cell-based bone tissue engineering

2019 ◽  
Vol 34 (6) ◽  
pp. 361-367 ◽  
Author(s):  
Chaolemeng Bao ◽  
Mark S.K. Chong ◽  
Lei Qin ◽  
Yiping Fan ◽  
Erin Yiling Teo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tricalcium Phosphate

scholarly journals 3D Printed Wavy Scaffolds Enhance Mesenchymal Stem Cell Osteogenesis

Micromachines ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 31 ◽  
Author(s):  
Shen Ji ◽  
Murat Guvendiren
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Human Mesenchymal Stem Cell ◽  
Calcium Deposition ◽  
Porous Scaffolds ◽  
Osteogenic Lineage ◽  
3D Printed

There is a growing interest in developing 3D porous scaffolds with tunable architectures for bone tissue engineering. Surface topography has been shown to control stem cell behavior including differentiation. In this study, we printed 3D porous scaffolds with wavy or linear patterns to investigate the effect of wavy scaffold architecture on human mesenchymal stem cell (hMSC) osteogenesis. Five distinct wavy scaffolds were designed using sinusoidal waveforms with varying wavelengths and amplitudes, and orthogonal scaffolds were designed using linear patterns. We found that hMSCs attached to wavy patterns, spread by taking the shape of the curvatures presented by the wavy patterns, exhibited an elongated shape and mature focal adhesion points, and differentiated into the osteogenic lineage. When compared to orthogonal scaffolds, hMSCs on wavy scaffolds showed significantly enhanced osteogenesis, indicated by higher calcium deposition, alkaline phosphatase activity, and osteocalcin staining. This study aids in the development of 3D scaffolds with novel architectures to direct stem osteogenesis for bone tissue engineering.

scholarly journals Mesenchymal Stem Cell–Encapsulated Collagen Microspheres for Bone Tissue Engineering

2010 ◽  
Vol 16 (2) ◽  
pp. 225-235 ◽  
Author(s):  
Barbara Pui Chan ◽  
Ting Yan Hui ◽  
Mei Yi Wong ◽  
Kevin Hak Kong Yip ◽  
Godfrey Chi Fung Chan
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals A pH-Triggered, Self-Assembled, and Bioprintable Hybrid Hydrogel Scaffold for Mesenchymal Stem Cell Based Bone Tissue Engineering

2019 ◽  
Vol 11 (9) ◽  
pp. 8749-8762 ◽  
Author(s):  
Chen Zhao ◽  
Nader Taheri Qazvini ◽  
Monirosadat Sadati ◽  
Zongyue Zeng ◽  
Shifeng Huang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Hydrogel Scaffold ◽  
Hybrid Hydrogel ◽  
Self Assembled

Bioprinting Organotypic Hydrogels with Improved Mesenchymal Stem Cell Remodeling and Mineralization Properties for Bone Tissue Engineering

2016 ◽  
Vol 5 (11) ◽  
pp. 1336-1345 ◽  
Author(s):  
Daniela Filipa Duarte Campos ◽  
Andreas Blaeser ◽  
Kate Buellesbach ◽  
Kshama Shree Sen ◽  
Weiwei Xun ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Cell Remodeling
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