scholarly journals Efficiency of a dexamethasone nanosuspension as an intratympanic injection for acute hearing loss

Drug Delivery ◽  
2021 ◽  
Vol 29 (1) ◽  
pp. 149-160
Author(s):  
So-Young Jung ◽  
Subin Kim ◽  
Zion Kang ◽  
Soonmin Kwon ◽  
Juhye Lee ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Intratympanic Injection ◽  
Acute Hearing Loss

scholarly journals Efficiency of a Dexamethasone Nanosuspension as an Intratympanic Injection for Acute Hearing Loss

2021 ◽  
Author(s):  
So-Young Jung ◽  
Zion Kang ◽  
Soonmin Kwon ◽  
Juhye Lee ◽  
Subin Kim ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Round Window ◽  
Round Window Membrane ◽  
In Vivo Test ◽  
Drug Concentrations ◽  
Intratympanic Injection ◽  
Acute Hearing Loss

Abstract Background: Dexamethasone sodium phosphate (Dex-SP) is the most commonly used drug for intratympanic injection in acute hearing loss, but its penetration efficiency into the inner ear is very low. To address this problem, we evaluated the possibility of dexamethasone nanosuspensions as intratympanic injection because the lipophilicity of drugs can affect their permeation of the round window membrane, an important pathway from the middle ear to the cochlea.Results: Three types of dexamethasone nanosuspensions were prepared; the dexamethasone nanocrystals in the three nanosuspensions were between approximately 250 and 350 nm in size. In order to compare the efficiency of Dex-SP and a dexamethasone nanosuspension in delivering dexamethasone to the inner ear, the concentrations of dexamethasone in perilymph and cochlear tissues were compared by liquid chromatography–mass spectrometry. The dexamethasone nanosuspensions showed significantly higher drug concentrations in perilymph and cochlear tissue than Dex-SP at 6 h; interestingly, animals treated with a nanosuspension showed a 26-fold higher dexamethasone concentration in the cochlear tissue than the Dex-SP group. In addition, the dexamethasone nanosuspension achieved better glucocorticoid receptor phosphorylation than Dex-SP both in vitro and in vivo, and in the ototoxic animal model, it showed a significantly better hearing protective effect than Dex-SP against ototoxic drugs. In safety evaluation, the nanosuspension showed no toxicity at concentrations up to 20 mg/mL in an in vivo test.Conclusions: A nanosuspension of dexamethasone was able to deliver dexamethasone to the cochlea very safely and efficiently and showed potential as a formula for intratympanic injection. In addition, it can be applied in studies on the delivery of various hydrophobic antioxidants to treat acute hearing loss.

ED management of acute hearing loss: review article

2020 ◽  
pp. 848-852
Author(s):  
Homood Almutairi ◽  
Yousef Alharbi ◽  
Muhannad Almohanna ◽  
Afaf Alnefisah ◽  
Abdulrahman Almutairi ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Review Article ◽  
Acute Hearing Loss

scholarly journals Elucidation of the Hdac2/Sp1/miR-204-5p/Bcl-2 axis as a modulator of cochlear apoptosis via in vivo/in vitro models of acute hearing loss

2021 ◽  
Vol 23 ◽  
pp. 1093-1109
Author(s):  
Lisheng Xie ◽  
Qiongqiong Zhou ◽  
Xiaorui Chen ◽  
Xiaoping Du ◽  
Zhibiao Liu ◽  
...  
Keyword(s):  
Hearing Loss ◽  
In Vitro Models ◽  
Acute Hearing Loss

Ears

2020 ◽  
Author(s):  
Peter Pruitt ◽  
Thomas Osborne Stair
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Acoustic Trauma ◽  
Tympanic Membrane Perforation ◽  
Sensorineural Hearing ◽  
Hearing Disorders ◽  
High Frequency Hearing Loss ◽  
Membrane Perforation ◽  
Acute Hearing Loss ◽  
Conductive Hearing

As the structure of the ear is made of little more than cartilage, a limited blood supply, and a thin layer of skin, trauma in this area can easily manifest from a variety of causes. Some common examples of trauma involve laceration, piercing (intentional or otherwise), infection causing chondritis, blunt trauma causing necrosis, rupture of the tympanic membrane, perforation of the ear drum, and acoustic trauma that may result in hearing disorders such as tinnitus and high-frequency hearing loss. Acute hearing loss shows in two forms: conductive hearing loss and sensorineural hearing loss, the latter of which is caused by damage to the anatomic or neurologic structures of the ear dedicated to hearing. Sensorineural hearing loss generally has a poor prognosis and mandates prompt referral to an otolaryngologist.  This review contains 4 figures, 13 tables, and 32 references. Keywords: Ear, auricular canal, trauma, otitis media, otitis externa, hearing loss, mastoiditis, cerumen, impaction

Sign in / Sign up

Export Citation Format

Share Document