PROCESS DEVELOPMENT FOR ROBUST REMOVAL OF AGGREGATES USING CATION EXCHANGE CHROMATOGRAPHY IN MONOCLONAL ANTIBODY PURIFICATION WITH IMPLEMENTATION OF QUALITY BY DESIGN

Antibody Purification

pH–conductivity hybrid gradient cation-exchange chromatography for process-scale monoclonal antibody purification

10.1016/j.chroma.2007.10.028 ◽

2007 ◽

Vol 1175 (1) ◽

pp. 69-80 ◽

Cited By ~ 30

Author(s):

Joe X. Zhou ◽

Shinta Dermawan ◽

Felix Solamo ◽

Greg Flynn ◽

Rosalind Stenson ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Antibody Purification ◽

Process Scale

Exploration of overloaded cation exchange chromatography for monoclonal antibody purification

10.1016/j.chroma.2011.08.008 ◽

2011 ◽

Cited By ~ 3

Author(s):

Hui F. Liu ◽

Beth McCooey ◽

Tiago Duarte ◽

Deanna E. Myers ◽

Terry Hudson ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Antibody Purification

Mechanistic modeling based process development for monoclonal antibody monomer-aggregate separations in multimodal cation exchange chromatography

10.1016/j.chroma.2019.05.056 ◽

2019 ◽

Vol 1602 ◽

pp. 317-325 ◽

Cited By ~ 1

Author(s):

Ling Zhang ◽

Siddharth Parasnavis ◽

Zhengjian Li ◽

Jie Chen ◽

Steven Cramer

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Process Development ◽

Exchange Chromatography ◽

Mechanistic Modeling ◽

Cation Exchange Chromatography

Characterization of the Acidic Species of a Monoclonal Antibody Using Weak Cation Exchange Chromatography and LC-MS

Analytical Chemistry ◽

10.1021/acs.analchem.5b02385 ◽

2015 ◽

Vol 87 (17) ◽

pp. 9084-9092 ◽

Cited By ~ 24

Author(s):

Gomathinayagam Ponniah ◽

Adriana Kita ◽

Christine Nowak ◽

Alyssa Neill ◽

Yekaterina Kori ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Weak Cation Exchange

Utilizing mAb Adsorption Isotherms To Direct Process Development of a Strong Cation-Exchange Chromatography Step

ACS Symposium Series - Developments in Biotechnology and Bioprocessing ◽

10.1021/bk-2013-1125.ch004 ◽

2013 ◽

pp. 51-65 ◽

Cited By ~ 1

Author(s):

Christopher Gillespie

Keyword(s):

Cation Exchange ◽

Adsorption Isotherms ◽

Process Development ◽

Exchange Chromatography ◽

Direct Process ◽

Strong Cation Exchange ◽

Strong Cation Exchange Chromatography ◽

Chromatography Step

Effects of salt-induced reversible self-association on the elution behavior of a monoclonal antibody in cation exchange chromatography

10.1016/j.chroma.2014.08.048 ◽

2014 ◽

Vol 1362 ◽

pp. 186-193 ◽

Cited By ~ 28

Author(s):

Haibin Luo ◽

Nathaniel Macapagal ◽

Kelcy Newell ◽

Adrian Man ◽

Arun Parupudi ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Elution Behavior ◽

Self Association

Alkaline cation-exchange chromatography for the reduction of aggregate and a mis-formed disulfide variant in a bispecific antibody purification process

Journal of Chromatography B ◽

10.1016/j.jchromb.2014.11.002 ◽

2015 ◽

Vol 975 ◽

pp. 1-8 ◽

Cited By ~ 7

Author(s):

Troii Hall ◽

Joseph J. Wilson ◽

Tammy J. Brownlee ◽

James R. Swartling ◽

Sarah E. Langan ◽

...

Keyword(s):

Cation Exchange ◽

Bispecific Antibody ◽

Exchange Chromatography ◽

Purification Process ◽

Antibody Purification ◽

Alkaline Cation

Surface induced three-peak elution behavior of a monoclonal antibody during cation exchange chromatography

10.1016/j.chroma.2016.10.061 ◽

2016 ◽

Vol 1474 ◽

pp. 85-94 ◽

Cited By ~ 15

Author(s):

Jing Guo ◽

Arch D. Creasy ◽

Gregory Barker ◽

Giorgio Carta

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Elution Behavior

Monoclonal antibody capture and viral clearance by cation exchange chromatography

Biotechnology and Bioengineering ◽

10.1002/bit.24480 ◽

2012 ◽

Vol 109 (8) ◽

pp. 2048-2058 ◽

Cited By ~ 23

Author(s):

G.R. Miesegaes ◽

S. Lute ◽

D.M. Strauss ◽

E.K. Read ◽

A. Venkiteshwaran ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cation Exchange ◽

Exchange Chromatography ◽

Viral Clearance ◽

Antibody Capture

Cation exchange chromatography provides effective retrovirus clearance for antibody purification processes

Biotechnology and Bioengineering ◽

10.1002/bit.23300 ◽

2011 ◽

Vol 109 (1) ◽

pp. 157-165 ◽

Cited By ~ 15

Author(s):

Lisa Connell-Crowley ◽

Thao Nguyen ◽

Julia Bach ◽

Shivanthi Chinniah ◽

Houman Bashiri ◽

...

Keyword(s):

Cation Exchange ◽

Exchange Chromatography ◽

Antibody Purification