Identification of Tau and SOD1 gene mutation in a small Chinese Han pedigree of adult amyotrophic lateral sclerosis

Neurocase ◽  
2013 ◽  
Vol 19 (5) ◽  
pp. 497-504 ◽  
Author(s):  
Renshi Xu ◽  
Bei Shao ◽  
Chengsi Wu ◽  
Yunzhu Yang ◽  
Hanmin Wang ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gene Mutation ◽  
Sod1 Gene ◽  
Chinese Han ◽  
Lateral Sclerosis

A novel SOD1 gene mutation in a Korean family with amyotrophic lateral sclerosis

2003 ◽  
Vol 206 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Nam-Hee Kim ◽  
Hyun-Jung Kim ◽  
Manho Kim ◽  
Kwang-Woo Lee
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gene Mutation ◽  
Sod1 Gene ◽  
Korean Family ◽  
Lateral Sclerosis

α-Synuclein coaggregation in familial amyotrophic lateral sclerosis with SOD1 gene mutation

2013 ◽  
Vol 44 (6) ◽  
pp. 1171-1176 ◽  
Author(s):  
Yo-ichi Takei ◽  
Kenya Oguchi ◽  
Hiroshi Koshihara ◽  
Akiyo Hineno ◽  
Akinori Nakamura ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gene Mutation ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Sod1 Gene ◽  
Lateral Sclerosis

TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation

2007 ◽  
Vol 113 (5) ◽  
pp. 535-542 ◽  
Author(s):  
Chun-Feng Tan ◽  
Hiroto Eguchi ◽  
Asako Tagawa ◽  
Osamu Onodera ◽  
Takuya Iwasaki ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Gene Mutation ◽  
Familial Amyotrophic Lateral Sclerosis ◽  
Sod1 Gene ◽  
Neuronal Inclusions ◽  
Lateral Sclerosis

Amyotrophic lateral sclerosis: a new missense mutation in the SOD1 gene

2013 ◽  
Vol 34 (6) ◽  
pp. 1709.e3-1709.e5 ◽  
Author(s):  
Rosanna Tortelli ◽  
Francesca Luisa Conforti ◽  
Rosa Cortese ◽  
Eustachio D'Errico ◽  
Eugenio Distaso ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Missense Mutation ◽  
Sod1 Gene ◽  
Lateral Sclerosis

Amyotrophic Lateral Sclerosis Clinical Trials

2017 ◽  
Author(s):  
Katharine A. Nicholson ◽  
James D. Berry
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Trial Design ◽  
Sod1 Gene ◽  
Trial Methodology ◽  
Quarter Century ◽  
New Era ◽  
Clinical Trial Methodology ◽  
The Past ◽  
Current State ◽  
Lateral Sclerosis

The current state of amyotrophic lateral sclerosis (ALS) trial design is best understood within the context of ALS research over the past quarter century. Before the early 1990s, trials in ALS were typically small and clinical trial methodology was less rigorous than it is today. With the discovery of the SOD1 gene mutation in the early 1990s, a new era of excitement and innovation for ALS research began. Since then, the number of ALS trials has steadily increased and trial design and methodology has become increasingly sophisticated.

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