Smell tests to distinguish Parkinson’s disease from other neurological disorders: a systematic review and meta-analysis

Author(s):  
Cintia C. G. Alonso ◽  
Fernanda G. Silva ◽  
Leonardo O. P. Costa ◽  
Sandra M. S. F Freitas
2018 ◽  
Vol 32 (9) ◽  
pp. 1157-1168 ◽  
Author(s):  
Stanley John Winser ◽  
William WN Tsang ◽  
Karthikeyan Krishnamurthy ◽  
Priya Kannan

Objective: To evaluate the effect of Tai Chi on balance and reducing falls incidence in neurological disorders. Data sources: AMED, Embase, Web of Science, SCOPUS, EBSCO and Medline from inception until February 2018. Review method: Randomized controlled trials of Tai Chi compared with active or no treatment control, measuring balance with the Berg Balance Scale or the Timed Up and Go Test and number of falls in neurological disorders were included. Methodological quality was assessed using PEDro and quality of evidence using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system. Results: A total of 10 studies involving 720 participants were reviewed. Seven studies were in Parkinson’s disease and three in stroke. Seven studies were of high methodological quality and three were low. Meta-analyses of balance measured with the Timed Up and Go Test in Parkinson’s disease revealed a statistically significant effect of Tai Chi compared to no treatment (weighted mean difference (WMD), –2.13; 95% confidence interval (CI), −3.26 to −1.00; P < 0.001) and was insignificant (WMD, −0.19; 95% CI, −1.74 to 1.35; P = 0.81) when compared with active treatment. Tai Chi significantly reduced falls incidence in Parkinson’s disease (odds ratio (OR), 0.47; 95% CI, 0.29 to 0.77; P = 0.003) and stroke (OR, 0.21; 95% CI, 0.09 to 0.48; P < 0.001). Balance measured with the Timed Up and Go Test comparing Tai Chi and active treatment was insignificant (WMD, 0.45; 95% CI, –3.43 to 2.54; P = 0.77) in stroke. Conclusion: Tai Chi is effective in reducing falls incidence in Parkinson’s disease and stroke. This systematic review did not find high-quality studies among other neurological disorders.


2021 ◽  
Author(s):  
Frouke A.P. Nijhuis ◽  
Rianne Esselink ◽  
Rob M.A. Bie ◽  
Hans Groenewoud ◽  
Bastiaan R. Bloem ◽  
...  

Author(s):  
Mandy Roheger ◽  
Moritz Ernst ◽  
Ann-Kristin Folkerts ◽  
Fabian Krohm ◽  
Hannah Liebermann-Jordanidis ◽  
...  

2020 ◽  
Vol 35 (9) ◽  
pp. 1509-1531 ◽  
Author(s):  
Roopa Rajan ◽  
Laura Brennan ◽  
Bastiaan R. Bloem ◽  
Nabila Dahodwala ◽  
Joan Gardner ◽  
...  

2017 ◽  
Vol 15 (5) ◽  
pp. 3383-3389 ◽  
Author(s):  
Giovanni Mostile ◽  
Calogero Edoardo Cicero ◽  
Loretta Giuliano ◽  
Mario Zappia ◽  
Alessandra Nicoletti

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