scholarly journals Aspartic peptidase of Phialophora verrucosa as target of HIV peptidase inhibitors: blockage of its enzymatic activity and interference with fungal growth and macrophage interaction

2020 ◽  
Vol 35 (1) ◽  
pp. 629-638
Author(s):  
Marcela Q. Granato ◽  
Ingrid S. Sousa ◽  
Thabatta L. S. A. Rosa ◽  
Diego S. Gonçalves ◽  
Sergio H. Seabra ◽  
...  
Keyword(s):  
Enzymatic Activity ◽  
Fungal Growth ◽  
Peptidase Inhibitors ◽  
Aspartic Peptidase ◽  
Phialophora Verrucosa

The Widespread Anti-Protozoal Action of HIV Aspartic Peptidase Inhibitors: Focus on Plasmodium spp., Leishmania spp. and Trypanosoma cruzi

2017 ◽  
Vol 17 (11) ◽  
pp. 1303-1317 ◽  
Author(s):  
Marta Branquinha ◽  
Leandro Sangenito ◽  
Catia Sodre ◽  
Lucimar Kneipp ◽  
Claudia d'Avila-Levy ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Peptidase Inhibitors ◽  
Aspartic Peptidase ◽  
Leishmania Spp

How relevant are microbial traits to understand soil biogeochemical cycles? 

2021 ◽  
Author(s):  
Tessa Camenzind ◽  
Johannes Lehmann ◽  
Anika Lehmann ◽  
Carlos A. Aguilar-Trigueros ◽  
Matthias C. Rillig
Keyword(s):  
Enzymatic Activity ◽  
Fungal Growth ◽  
Biogeochemical Cycles ◽  
Model Organisms ◽  
Soil System ◽  
Microbial Physiology ◽  
Carbon Use Efficiency ◽  
N Supply ◽  
Use Efficiency

<p>Our knowledge about the role of microbial organisms as drivers of soil biogeochemical cycles is mainly based on soil analyses, and the physiological information that exists for few microbial model organisms. In soil, measurements of process rates and element contents can be related to the apparent activity of the microbial community, though conclusions are often indirect - actual microbial physiology and diversity remains hidden. By contrast, analyses of microbial physiology under controlled conditions are hardly representative of the vast diversity of microorganisms in soil, and a transfer of these findings to complex soil systems is challenging. Thus, we argue that a better exchange among these ecological disciplines will lead to a valuable transfer of relevant questions, knowledge and improved understanding of the role of microbes in soil and its responses to environmental change. <br>Here, we provide examples of an evaluation of microbial parameters relevant in soil biogeochemical cycles, analysing traits in a collection of 31 saprobic fungi in response to varying substrate conditions. The large dataset allowed to test several assumptions and conclusions derived from soil system analyses exemplarily for soil fungi. Specifically, we (1) evaluated the optimum C:N:P (carbon:nitrogen:phosphorus) substrate ratio for fungal growth and activity, (2) assessed the responses in carbon-use efficiency and enzyme activity to N deficiency, (3) analyzed the relevance of C versus N supply for fungal growth and activity under varying substrate conditions and (4) tested the assumption of microbial stoichiometric homeostasis, that represents a basic principle in soil ecological stoichiometry. <br>Fungal responses to changes in N and C availability were partly consistent with expectations, e.g. regarding general nutrient demands, though as often discussed C availability appeared more relevant for growth especially in complex substrates. Enzymatic activity and respiration also positively correlated with N availability, resulting in decreased carbon-use efficiency at high N supply. These findings, for example, contradict certain conclusions in soil analyses, namely that N limitations will result in “N mining” (high enzymatic activity), while the excess of C causes “overflow respiration” and reduced CUE. Regarding fungal C:N:P ratios, those were only related to nutrient demands when growing in simple media, while in soil substrate such relations seem more complex. Contradicting the assumption of microbial homeostasis in soil, fungal individuals showed more flexible C:N:P ratios than expected, though the degree of flexibility varied among isolates. In general, the results also reveal a large trait variation among different isolates, with several traits showing a phylogenetic signal, indicating variations in microbial activity depending on community composition.<br>Finally, we want to raise and discuss several emerging questions: How relevant is a deeper understanding of microbial physiology to understand soil biogeochemical processes? How do we include the variability of traits in diverse soil communities – are average values informative, or can we proceed with useful categories? And how can methods in soil science and microbial ecology be merged best to allow fruitful knowledge transfer?</p>

A comparison of lignin oxidation, enzymatic activity and fungal growth during white-rot decay of wheat straw

2008 ◽  
Vol 39 (8) ◽  
pp. 945-951 ◽  
Author(s):  
Steven A. Robertson ◽  
Sharon L. Mason ◽  
Ethan Hack ◽  
Geoffrey D. Abbott
Keyword(s):  
Enzymatic Activity ◽  
Wheat Straw ◽  
Fungal Growth ◽  
White Rot ◽  
Lignin Oxidation

HIV aspartic peptidase inhibitors are effective drugs against the trypomastigote form of the human pathogen Trypanosoma cruzi

2016 ◽  
Vol 48 (4) ◽  
pp. 440-444 ◽  
Author(s):  
Leandro S. Sangenito ◽  
Diego S. Gonçalves ◽  
Sergio H. Seabra ◽  
Claudia M. d'Avila-Levy ◽  
André L.S. Santos ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Human Pathogen ◽  
Peptidase Inhibitors ◽  
Aspartic Peptidase ◽  
Trypomastigote Form ◽  
Effective Drugs

Aspartic Peptidase Inhibitors: Implications in Drug Development

2003 ◽  
Vol 38 (2) ◽  
pp. 89-119 ◽  
Author(s):  
Chandravanu Dash ◽  
Aarohi Kulkarni ◽  
Ben Dunn ◽  
Mala Rao
Keyword(s):  
Drug Development ◽  
Peptidase Inhibitors ◽  
Aspartic Peptidase

Solid-Phase Synthesis of Aspartic Peptidase Inhibitors:  3-Alkoxy-4-Aryl Piperidines

2001 ◽  
Vol 3 (17) ◽  
pp. 2625-2628 ◽  
Author(s):  
Matthew G. Bursavich ◽  
Daniel H. Rich
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Peptidase Inhibitors ◽  
Aspartic Peptidase

Corrigendum to “A comparison of lignin oxidation, enzymatic activity and fungal growth during white-rot decay of wheat straw” [Org. Geochem. 39 (2008) 945–951]

2008 ◽  
Vol 39 (12) ◽  
pp. 1816
Author(s):  
Steven A. Robertson ◽  
Sharon L. Mason ◽  
Ethan Hack ◽  
Geoffrey D. Abbott
Keyword(s):  
Enzymatic Activity ◽  
Wheat Straw ◽  
Fungal Growth ◽  
White Rot ◽  
Lignin Oxidation

scholarly journals HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events in Fonsecaea pedrosoi

2017 ◽  
Vol 8 ◽  
Author(s):  
Vanila F. Palmeira ◽  
Daniela S. Alviano ◽  
Lys A. Braga-Silva ◽  
Fátima R. V. Goulart ◽  
Marcela Q. Granato ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Fonsecaea Pedrosoi ◽  
Peptidase Inhibitors ◽  
Aspartic Peptidase ◽  
Surface Molecules
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