Maternal serum and fetal cord-blood ischemia-modified albumin concentrations in normal pregnancy and preeclampsia: a systematic review and meta-analysis

2017 ◽  
Vol 31 (24) ◽  
pp. 3255-3266 ◽  
Author(s):  
Varikasuvu Seshadri Reddy ◽  
Pragathi Duggina ◽  
Mrudula Vedhantam ◽  
Munikumar Manne ◽  
Neelakant Varma ◽  
...  
Author(s):  
Kumar Vivek ◽  
Balachandar Thangappazham ◽  
Alekya Vykunta ◽  
Paresh P. Kulkarni ◽  
Faustino R. Pérez-López ◽  
...  

2020 ◽  
Author(s):  
Farzaneh Mardali ◽  
Somaye Fatahi ◽  
Maryam Alinaghizadeh ◽  
Hamed Kord Varkaneh ◽  
Mohammad Hassan Sohouli ◽  
...  

Abstract Context Some evidence has shown an association between maternal vitamin B12 levels and the development of preeclampsia in pregnant women, but the relationship between preeclampsia and vitamin B12 is not clear. Objective The aim of this systematic review was to compare serum vitamin B12 levels in women with preeclampsia with those in normotensive pregnant women. Data Sources The PubMed/MEDLINE, Scopus, and Web of Science databases were searched up to August 2019, along with the reference lists of included articles. Study Selection The literature was searched for observational studies that investigated vitamin B12 levels in women with preeclampsia. Data Extraction Data were extracted independently by 2 authors. Data were pooled using a random-effects model. Results Vitamin B12 levels in women with preeclampsia were significantly lower than those in healthy women (mean, −15.24 pg/mL; 95%CI, −27.52 to −2.954; P < 0.015), but heterogeneity between studies was high (I2 = 97.8%; P = 0.0103). Subgroup analyses based on folic acid supplementation, homocysteine concentrations, and gestational age at the time of sampling for vitamin B12 assessment did not identify the sources of heterogeneity. Conclusions Women with preeclampsia had significantly lower vitamin B12 concentrations than normotensive pregnant women.


2020 ◽  
Vol 37 (10) ◽  
pp. 1055-1060 ◽  
Author(s):  
Ziyi Yang ◽  
Yi Liu

Objective The aim of this study is to summarize currently available evidence on vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study Design A systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analysis Statement. Results A total of 22 studies comprising 83 neonates born to mothers diagnosed with coronavirus disease 2019 were included in the present systematic review. Among these neonates, three were confirmed with SARS-CoV-2 infection at 16, 36, and 72 hours after birth, respectively, by nasopharyngeal swab real-time polymerase chain reaction (RT-PCR) tests; another six had elevated virus-specific antibody levels in serum samples collected after birth, but negative RT-PCR test results. However, without positive RT-PCR tests of amniotic fluid, placenta, or cord blood, there is a lack of virologic evidence for intrauterine vertical transmission. Conclusion There is currently no direct evidence to support intrauterine vertical transmission of SARS-CoV-2. Additional RT-PCR tests on amniotic fluid, placenta, and cord blood are needed to ascertain the possibility of intrauterine vertical transmission. For pregnant women infected during their first and second trimesters, further studies focusing on long-term outcomes are needed. Key Points


2000 ◽  
Vol 70 ◽  
pp. C25-C25
Author(s):  
T. Lam ◽  
I. Schulz-Lobmeyr ◽  
B.W. Hartmann ◽  
O. Preyed ◽  
P. Wagenbichler

BMJ ◽  
2013 ◽  
Vol 346 (mar26 4) ◽  
pp. f1169-f1169 ◽  
Author(s):  
F. Aghajafari ◽  
T. Nagulesapillai ◽  
P. E. Ronksley ◽  
S. C. Tough ◽  
M. O'Beirne ◽  
...  

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