Cord blood zinc status effects on pregnancy outcomes and its relation with maternal serum zinc levels: a systematic review and meta-analysis

2019 ◽  
Vol 16 (4) ◽  
pp. 366-376 ◽  
Author(s):  
Sevginur Akdas ◽  
Nuray Yazihan
Keyword(s):  
Systematic Review ◽  
Cord Blood ◽  
Pregnancy Outcomes ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Zinc Status ◽  
Zinc Levels ◽  
Blood Zinc ◽  
Serum Zinc Levels

scholarly journals Comparison of maternal serum and neonatal cord blood levels of zinc in relation to birth weight and period of gestation

2021 ◽  
Vol 8 (8) ◽  
pp. 1349
Author(s):  
Shabbeer Ahmed ◽  
Avula Kanthi Sagar
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Zinc Deficiency ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Blood Levels ◽  
P Value ◽  
Zinc Levels ◽  
Blood Zinc ◽  
Serum Zinc Levels

Background: Women are at increased risk of zinc deficiency during pregnancy because of high fetal requirements for zinc. Severe maternal zinc deficiency has been associated with poor fetal growth, spontaneous abortion and congenital malformations (i.e., anencephaly), whereas milder forms of zinc deficiency have been associated with low birth weight (LBW), intrauterine growth retardation, and preterm delivery. However, the research relating maternal zinc status and birth weight has not produced consistent results. This study has been undertaken to confirm the association between maternal serum zinc concentration and birth weight and period of gestation in setting like India.Methods: A total of 100 new-borns were included and divided into two groups, the ‘study group’ had babies with birth weight <2.5 kg and control group’ with babies >2.5 kg birth weight. Cord blood from the new-borns and serum samples of mothers were collected and the zinc levels were measured.Results: The correlation of cord blood and the maternal serum zinc levels were assessed in relation to birth weight and the gestational age. The results were compared between the two groups. The difference in values between the two groups was statistically significant, maternal serum zinc levels and birth weight (84.78±21.62 vs 66.04±18.66) (‘P’ value 0.04), cord blood zinc levels and birth weight (98.44±22.59 vs 79.78±19.54) (‘P’ value <0.001). The maternal serum and cord blood zinc was compared between the preterm and term; the results were statistically significant.Conclusions: The maternal and cord blood levels of zinc are correlated well with the birth weight and the gestational age at delivery. Supplementation of zinc during gestation might help reduce the incidence of IUGR and the risk of prematurity.

Serum zinc levels and efficacy of zinc treatment in acne vulgaris: A systematic review and meta‐analysis

2020 ◽  
Vol 33 (6) ◽  
Author(s):  
Brittany E. Yee ◽  
Phillip Richards ◽  
Jennifer Y. Sui ◽  
Amanda Fleming Marsch
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Acne Vulgaris ◽  
Serum Zinc ◽  
Zinc Treatment ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ling-Jun Wang ◽  
Ming-Qing Wang ◽  
Rong Hu ◽  
Yi Yang ◽  
Yu-Sheng Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Subgroup Analysis ◽  
Zinc Supplementation ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Maintenance Hemodialysis ◽  
Randomized Controlled ◽  
Zinc Levels ◽  
Serum Zinc Levels

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.

A Prospective Survey of Serial Maternal Serum Zinc Levels and Pregnancy Outcome

1988 ◽  
Vol 7 (3) ◽  
pp. 430-433 ◽  
Author(s):  
Akimasa Higashi ◽  
Akiko Tajiri ◽  
Makoto Matsukura ◽  
Ichiro Matsuda
Keyword(s):  
Pregnancy Outcome ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Prospective Survey ◽  
Zinc Levels ◽  
Serum Zinc Levels

Serum zinc levels of cord blood: Relation to birth weight and gestational period

2015 ◽  
Vol 30 ◽  
pp. 180-183 ◽  
Author(s):  
Tahiry Gómez ◽  
Leticia Bequer ◽  
Angel Mollineda ◽  
Olga González ◽  
Mireisy Diaz ◽  
...  
Keyword(s):  
Birth Weight ◽  
Cord Blood ◽  
Serum Zinc ◽  
Gestational Period ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Higher serum zinc levels may reduce the risk of cervical cancer in Asian women: A meta-analysis

2018 ◽  
Vol 46 (12) ◽  
pp. 4898-4906 ◽  
Author(s):  
Yueying Xie ◽  
Junjie Wang ◽  
Xiaoya Zhao ◽  
Xuli Zhou ◽  
Xiaohui Nie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Asian Women ◽  
China National Knowledge Infrastructure ◽  
Cervical Cancer Risk ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objective This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. Methods PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression asymmetry test. Results Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD –1.379, 95% CI –1.527, –1.231), with high heterogeneity ( I2 = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD –1.391, 95% CI –1.543, –1.239). Conclusions Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.

Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis

2021 ◽  
Vol 25 (2) ◽  
pp. 407-415
Author(s):  
Sadeq A. Al-Maweri ◽  
Esam Halboub ◽  
Hesham Mohammed Al-Sharani ◽  
Anas Shamala ◽  
Ahlam Al-Kamel ◽  
...  
Keyword(s):  
Sequential Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Trial Sequential Analysis ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals A study of zinc level in cord blood of neonates and its relationship with antropometric measurements in the neonates: a descriptive cross-sectional study

2019 ◽  
Vol 6 (2) ◽  
pp. 722
Author(s):  
Syed Mohamed ◽  
Santosh Kumar ◽  
J. Kumutha
Keyword(s):  
Cord Blood ◽  
Growth Parameters ◽  
Serum Zinc ◽  
Cross Sectional Study ◽  
Zinc Level ◽  
Cross Sectional ◽  
Medical College ◽  
The Mean ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: During pregnancy, fast growth and cell differentiation takes place in both mother and foetus. Maternal nutritional factors play an important role in the growth of the neonate. Among the micronutrient zinc is an important micronutrient whose deficiency is associated with poor pregnancy outcomes. The objective the current study was to evaluate the relationship of serum zinc concentration of the maternal blood and the neonatal cord blood with that of the infant’s anthropometric measurements.Methods: A descriptive cross-sectional study was performed under the Department of Neonatology, Saveetha medical college. Duration of the study was from April 2017 to June 2018. The study included 82 singleton mother baby dyads born in Saveetha medical college. Anthropometric measurements such as birth weight, head circumference, neonate length apart from other clinical features of both the mother and neonates were recorded for statistical analysis. Serum zinc levels were estimated using 2-(5-bromo-2-pyridylazo)-5-(N-Propyl-N-sulfopropylamino)-phenol (5-Br-PAPS) protocol.Results: The mean maternal age of the study population is 25.3±2.3 years. Majority of the mother had natural mode of delivery (57%). The mean cord serum zinc level was found to be 94.0±1.6microgram /dl and the mother’s serum zinc level was 93.8±30.7microgram /dl (range from 49 to 171microgram /dl) which was not found to be statistically significant. Serum zinc levels of the cord was compared with the child anthropometrics and mother’s serum zinc levels to assess for the significance, but there was no correlation observed between the umbilical cord, and the birth weight (r=0.03), length of the child (r=-0.02), head circumference (r=-0.07) and mothers serum zinc levels (r=-0.002).Conclusions: According to our results authors were unable to establish a relationship between Neonates growth parameters and zinc levels in neonates cord blood and zinc levels in the mother. Further studies with a larger sample size and prospective design would establish a causal relationship between zinc and growth parameters in the neonate.

scholarly journals SMALL BABIES

2005 ◽  
Vol 12 (03) ◽  
pp. 336-339
Author(s):  
MUHAMMAD ASHRAF ◽  
Zamir Ahmad ◽  
MUHAMMAD NASARULLAH KHAN ◽  
Tariq Ferroz Khawaja ◽  
MUHAMMAD AYUB KHAN ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Gestational Age ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Maternal Complications ◽  
Metallic Component ◽  
Zinc Levels ◽  
Relationship Of ◽  
The Relationship ◽  
Serum Zinc Levels

Zinc is an essential trace mineral. It is considered a growth factor as it isthe metallic component of enzymes DNA polymerase, DNA dependent RNA polymerase and thymidine kinase.Objective: To find out the relationship of maternal serum zinc levels with birth weight of the babies. Period: January1989 to May, 1991. Setting: Lady Wellingdon Hospital Lahore, King Edward College, Lahore and MetallurgyDepartment PCSIR Laboratories, Lahore. Design: Prospective study Patients & methods: Among the 216 registeredpregnant women 46 subjects had no feto-maternal complications during pregnancy and they delivered babies havingbirth weight adequate for Gestational Age (AGA). Thirteen women gave birth to babies Small for Gestational Age(SGA). Blood samples were taken at the end of each trimester and serum zinc was measured by atomic absorptionspectrophotometer. Results: Serum zinc levels were significantly low (P<0.001) throughout pregnancy in women givingbirth to SGA babies. Conclusion: Serum zinc levels throughout the course of pregnancy are associated with intrauterinegrowth of the babies.b

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