Synthesis and cytotoxic activity of novel acyclic nucleoside analogues with functionality in click chemistry

2018 ◽  
Vol 37 (1) ◽  
pp. 53-66
Author(s):  
Michał Gładysz ◽  
Piotr Ruszkowski ◽  
Jan Milecki
Keyword(s):  
Cytotoxic Activity ◽  
Click Chemistry ◽  
Nucleoside Analogues ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside

scholarly journals Synthesis and Cytotoxic Activity of New Thiazolopyrimidine Sugar Hydrazones and Their Derived Acyclic Nucleoside Analogues

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 399
Author(s):  
Ebtesam A. Basiony ◽  
Allam A. Hassan ◽  
Zahra M. Al-Amshany ◽  
Ahmed A. Abd-Rabou ◽  
Adel A.-H. Abdel-Rahman ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Nucleoside Analogues ◽  
Human Breast ◽  
Human Colorectal Cancer ◽  
Mcf7 Cells ◽  
Sugar Hydrazones ◽  
Acyclic Nucleoside Analogues ◽  
Hct 116 ◽  
Acyclic Nucleoside

New thienyl- or chlorophenyl-substituted thiazolopyrimidine derivatives and their derived sugar hydrazones incorporating acyclic d-galactosyl or d-xylosyl sugar moieties in addition to their per-O-acetylated derivatives were synthesized. Heterocyclization of the formed sugar hydrazones afforded the derived acyclic nucleoside analogues possessing the 1,3,4-oxadiazoline as modified nucleobase via acetylation followed by the cyclization process. The cytotoxic activity of the synthesized compounds was studied against human breast cancer MCF7 and MDA-MB-231 cell lines as well as human colorectal cancer HCT 116 and Caco-2 cell lines. High activities were revealed by compounds 1, 8, 10, 11, and 13 against Caco-2 and MCF7 cells in addition to moderate activities exhibited by other compounds against HCT116 or MDA-MB-231 cells.

Acyclic nucleoside analogues derived from 2-azapurines

1993 ◽  
Vol 58 (s1) ◽  
pp. 250-252 ◽  
Author(s):  
D. Hocková ◽  
A. Holý ◽  
H. Dvořáková
Keyword(s):  
Nucleoside Analogues ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside

Asymmetric synthesis of both enantiomers of two acyclic nucleoside analogues related to d4T and acyclovir

2002 ◽  
Vol 43 (6) ◽  
pp. 989-991 ◽  
Author(s):  
David F Ewing ◽  
Virginie Glaçon ◽  
Grahame Mackenzie ◽  
Christophe Len
Keyword(s):  
Asymmetric Synthesis ◽  
Nucleoside Analogues ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside

Synthesis of acyclic nucleoside analogues based on 1,2,4-triazolo[1,5-a]pyrimidin-7-ones by one-step Vorbrüggen glycosylation

Tetrahedron ◽  
2014 ◽  
Vol 70 (6) ◽  
pp. 1298-1305 ◽  
Author(s):  
Igor A. Khalymbadzha ◽  
Tatyana S. Shestakova ◽  
Julia O. Subbotina ◽  
Oleg S. Eltsov ◽  
Alexandra A. Musikhina ◽  
...  
Keyword(s):  
Nucleoside Analogues ◽  
Acyclic Nucleoside Analogues ◽  
One Step ◽  
Acyclic Nucleoside

ChemInform Abstract: Synthesis and Antimicrobial Activity of New 1,2,3-Triazolopyrimidine Derivatives and Their Glycoside and Acyclic Nucleoside Analogues.

ChemInform ◽  
2012 ◽  
Vol 43 (49) ◽  
pp. no-no
Author(s):  
Wael A. El-Sayed ◽  
Omar M. Ali ◽  
Merfat S. Faheem ◽  
Ibrahim F. Zied ◽  
Adel A.-H. Abdel-Rahman
Keyword(s):  
Antimicrobial Activity ◽  
Nucleoside Analogues ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

2006 ◽  
Vol 49 (14) ◽  
pp. 4183-4195 ◽  
Author(s):  
Corinne Nguyen ◽  
Gian Filippo Ruda ◽  
Alessandro Schipani ◽  
Ganasan Kasinathan ◽  
Isabel Leal ◽  
...  
Keyword(s):  
Nucleoside Analogues ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside

N-Acetylneuraminic acid aldolase-catalyzed synthesis of acyclic nucleoside analogues carrying a 4-hydroxy-2-oxoacid moiety

2019 ◽  
Vol 121 ◽  
pp. 73-77
Author(s):  
Mariano J. Nigro ◽  
Martín A. Palazzolo ◽  
Diego Colasurdo ◽  
Adolfo M. Iribarren ◽  
Elizabeth S. Lewkowicz
Keyword(s):  
Nucleoside Analogues ◽  
Acetylneuraminic Acid ◽  
Acyclic Nucleoside Analogues ◽  
Acyclic Nucleoside
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