Association between FTO gene polymorphisms and breast cancer: the role of estrogen

Night shift work has been associated with an increased risk of breast cancer pointing to a role of circadian disruption. We investigated the role of circadian clock gene polymorphisms and their interaction with nightwork in breast cancer risk in a population-based case–control study in France including 1126 breast cancer cases and 1174 controls. We estimated breast cancer risk associated with each of the 577 single nucleotide polymorphisms (SNPs) in 23 circadian clock genes. We also used a gene- and pathway-based approach to investigate the overall effect on breast cancer of circadian clock gene variants that might not be detected in analyses based on individual SNPs. Interactions with nightwork were tested at the SNP, gene, and pathway levels. We found that two SNPs inRORA(rs1482057 and rs12914272) were associated with breast cancer in the whole sample and among postmenopausal women. In this subpopulation, we also reported an association with rs11932595 inCLOCK, and withCLOCK,RORA, andNPAS2in the analyses at the gene level. Breast cancer risk in postmenopausal women was also associated with overall genetic variation in the circadian gene pathway (P=0.04), but this association was not detected in premenopausal women. There was some evidence of an interaction betweenPER1and nightwork in breast cancer in the whole sample (P=0.024), although the effect was not statistically significant after correcting for multiple testing (P=0.452). Our results support the hypothesis that circadian clock gene variants modulate breast cancer risk.

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Distinct role of endothelial nitric oxide synthase gene polymorphisms from menopausal status in the patients with sporadic breast cancer in Taiwan

Nitric Oxide ◽

10.1016/j.niox.2017.10.009 ◽

2018 ◽

Vol 72 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Chien-Hung Chen ◽

Szu-Hsien Wu ◽

Yang-Ming Tseng ◽

Ming-Feng Hou ◽

Li-Yu Tsai ◽

...

Keyword(s):

Breast Cancer ◽

Nitric Oxide ◽

Endothelial Nitric Oxide Synthase ◽

Gene Polymorphisms ◽

Sporadic Breast Cancer ◽

Menopausal Status ◽

Oxide Synthase ◽

Endothelial Nitric Oxide ◽

Distinct Role

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Meta-analysis of Studies Investigating Association between FTO Gene Polymorphisms and Breast Cancer

Asian Pacific Journal of Cancer Biology ◽

10.31557/apjcb.2019.4.4.75-79 ◽

2019 ◽

Vol 4 (4) ◽

pp. 75-79

Author(s):

Maryam Gholamalizadeh ◽

Saeid Doaei ◽

Ali Sanjari Moghadam ◽

Abolfazel Movafagh ◽

Seyedeh Zahra Mousavi Jarrahi ◽

...

Keyword(s):

Breast Cancer ◽

Gene Polymorphisms ◽

Lower Risk ◽

Web Of Science ◽

Meta Analysis ◽

Final Analysis ◽

Small Study ◽

Inverse Association ◽

Random Effects Model ◽

Fto Gene

Objectives: The aim of this study is to pool the result of studies on the association between FTO gene polymorphisms and breast cancer (BC). Material and Methods: We searched PubMed, Embase, Science Direct, Scopus, web of science, and Cochran to identify studies investigating the associations between the rs1477196 and rs9939609 polymorphisms and BC risk. We pooled adjusted odds ratios (ORs) as overall. ORs were estimated using a random effects model. Results: In total, 16 articles were included in the final analysis. Considering the dominant model of inheritance, there was an inverse association between the rs1477196 polymorphism and BC (OR 0.76 [0.64- 0.91]). There was not observable heterogeneity (I2: 0.0%, P=.867), but with a small study effect (b=1.19, P=.03) in this analysis. Moreover, there was not any association between the rs9939609 polymorphism and BC (OR 0.98 [0.79- 1.2]). There was not observable heterogeneity (I2: 23.1%, P=.27) and small study effect (b=-3.817, P=.303) in this analysis. Conclusions: The carriers of rs1477196 polymorphism of FTO are at lower risk for BC. Carriers of Rs9939609 polymorphism had no association with Breast cancer risk.

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