Understanding the relationship between esophageal motor disorders and reflux disease

A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge, there has not been any research work in the literature investigating the relationship between MD and GERD using their miRNA biomarkers. We adopt a phylogenetic analysis to analyze their miRNA biomarkers. From our analyzed results, the association between these two diseases can be explored through miRNA phylogeny. In addition to evidence from the phylogenetic analysis, we also demonstrate epidemiological evidence for the relationship between MD and GERD based on Taiwan biobank data.

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Current Therapeutic Options for Esophageal Motor Disorders as Defined by the Chicago Classification

Journal of Clinical Gastroenterology ◽

10.1097/mcg.0000000000000317 ◽

2015 ◽

pp. 1 ◽

Cited By ~ 3

Author(s):

Frank Zerbib ◽

Sabine Roman

Keyword(s):

Therapeutic Options ◽

Motor Disorders ◽

Esophageal Motor Disorders ◽

Chicago Classification

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Reflux aspiration associated with oesophageal dysmotility but not delayed liquid gastric emptying

Digestive Diseases ◽

10.1159/000514108 ◽

2020 ◽

Author(s):

Oleksandr Khoma ◽

Maite Jeanne Mendu ◽

Amita Nandini Sen ◽

Hans Van der Wall ◽

Gregory Leighton Falk

Keyword(s):

Gastric Emptying ◽

Reflux Disease ◽

Inclusion Criteria ◽

Treatment Resistant ◽

Oesophageal Motility ◽

Oesophageal Manometry ◽

Oesophageal Dysmotility ◽

The Relationship ◽

Clinical Subtype

Abstract Introduction Severe oesophageal dysmotility is associated with treatment resistant reflux and pulmonary reflux aspiration. Delayed solid gastric emptying (SGE) has been associated with oesophageal dysmotility, however the role of delayed liquid gastric emptying (LGE) in the pathophysiology of severe reflux disease remains unknown. The purpose of this study is to examine the relationship between delayed LGE, reflux aspiration and oesophageal dysmotility. Methods Data was extracted from a prospectively populated database of patients with severe treatment resistant gastro-oesophageal reflux disease (GORD). All patients with validated reflux aspiration scintigraphy (RASP) and oesophageal manometry were included in the analysis. Patients were classified by predominant clinical subtype as gastro-oesophageal (GOR) or laryngo-pharyngeal (LPR) reflux. LGE time of 22 minutes or longer was considered delayed. Results Inclusion criteria were met by 631 patients. Normal LGE time was found in 450 patients, whilst 181 had evidence of delayed LGE. Mean liquid half-clearance was 22.81min. Refux aspiration was evident in 240 patients (38%). Difference in the aspiration rates between delayed LGE (42%) and normal LGE (36%) was not significant (p=0.16). Severe ineffective oesophageal motility (IOM) was found in 70 patients (35%) and was independent of LGE time. Severe IOM was strongly associated with reflux aspiration (p<0.001). GOR dominant symptoms were more common in patients with delayed LGE (p=0.03). Conclusion Severe IOM was strongly associated with reflux aspiration. Delayed LGE is not associated with reflux aspiration or severe IOM. Delayed LGE is more prevalent in patients presenting with GOR dominant symptoms.

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