The Association between Depression and Gastroesophageal Reflux based on Phylogenetic Analysis of miRNA Biomarkers

2020 ◽  
Vol 27 (38) ◽  
pp. 6536-6547 ◽  
Author(s):  
Yi-Hau Chen ◽  
Hsiuying Wang
Keyword(s):  
Phylogenetic Analysis ◽  
Major Depression ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Research Work ◽  
Epidemiological Evidence ◽  
The Relationship ◽  
Global Population ◽  
Shed Light

A number of clinical studies have revealed that there is an association between major depression (MD) and gastroesophageal reflux disease (GERD). Both the diseases are shown to affect a large proportion of the global population. More advanced studies for understanding the comorbidity mechanism of these two diseases can shed light on developing new therapies of both diseases. To the best of our knowledge, there has not been any research work in the literature investigating the relationship between MD and GERD using their miRNA biomarkers. We adopt a phylogenetic analysis to analyze their miRNA biomarkers. From our analyzed results, the association between these two diseases can be explored through miRNA phylogeny. In addition to evidence from the phylogenetic analysis, we also demonstrate epidemiological evidence for the relationship between MD and GERD based on Taiwan biobank data.

The association between migraine and depression based on miRNA biomarkers and cohort studies

2020 ◽  
Vol 27 ◽  
Author(s):  
Yi-Hau Chen ◽  
Hsiuying Wang
Keyword(s):  
Statistical Analysis ◽  
Major Depression ◽  
Direct Evidence ◽  
Epidemiological Data ◽  
Underlying Mechanism ◽  
Evidence Based ◽  
Epidemiological Evidence ◽  
The Relationship ◽  
Global Population ◽  
Shed Light

Background: An association between migraine and Major Depression (MD) has been revealed in many clinical studies. Both diseases affect a large proportion of the global population. More understanding on the comorbidity mechanism of these two diseases can shed light on developing new therapies for both diseases. Methods: To the best of our knowledge, there have not been any researches in the literature based on microRNA (miRNA) biomarkers to investigate the relationship between MD and migraine. In this study, we discuss the association of these two diseases based on their miRNA biomarkers. In addition to miRNA biomarkers, we also demonstrate epidemiological evidence for their association based on Taiwan Biobank (TWB) data. Results: Among the 12 migraine miRNA biomarkers, 11 of them are related to MD. Only miR-181a has no direct evidence involved in the mechanism of MD. In addition to the biological biomarker evidence, the statistical analysis using the largescale epidemiologic data collected from TWB provides strong evidence on the relationship between MD and migraine. Conclusions: The evidence based on both molecular and epidemiological data reveals the significant association between MD and migraine. This result can help investigate the correlated underlying mechanism of these two diseases.

scholarly journals Prospective evaluation of the relationship between acute exacerbations of COPD and gastroesophageal reflux disease diagnosed by questionnaire

2011 ◽  
Vol 105 (10) ◽  
pp. 1531-1536 ◽  
Author(s):  
Kazuto Takada ◽  
Shuuichi Matsumoto ◽  
Eiji Kojima ◽  
Susumu Iwata ◽  
Shoutarou Okachi ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Prospective Evaluation ◽  
Acute Exacerbations ◽  
The Relationship

The Relationship Between Otitis Media With Effusion and Gastroesophageal Reflux Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Zeng-Hong Wu ◽  
Yun Tang ◽  
Xun Niu ◽  
Hai-Ying Sun ◽  
Xiong Chen
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Otitis Media ◽  
Reflux Disease ◽  
Otitis Media With Effusion ◽  
The Relationship
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