scholarly journals Vitamin B12 deficiency in the setting of nitrous oxide abuse: diagnostic challenges and treatment options in patients presenting with subacute neurological complications

2021 ◽  
pp. 1-7
Author(s):  
Sluyts Yasmine ◽  
Vanherpe Pieternel ◽  
Amir Rizvana ◽  
Vanhoenacker Filip ◽  
Vermeersch Pieter
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Treatment Options ◽  
Vitamin B12 Deficiency ◽  
Neurological Complications ◽  
B12 Deficiency

scholarly journals Subacute Combined Degeneration of the Spinal Cord due to Different Etiologies and Improvement of MRI Findings

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Azize Esra Gürsoy ◽  
Mehmet Kolukısa ◽  
Gülsen Babacan-Yıldız ◽  
Arif Çelebi
Keyword(s):  
Spinal Cord ◽  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Neurological Complication ◽  
Vitamin B12 Deficiency ◽  
Vegetarian Diet ◽  
Mri Findings ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency ◽  
Reversible Condition

Subacute combined degeneration (SCD) is a rare neurological complication of vitamin B12 deficiency, characterized by demyelination of the dorsal and lateral spinal cord. Herein, we describe three cases, who presented with SCD, one related to reduced intake of vitamin B12 because of a vegetarian diet and two related to nitrous oxide exposure during surgery. MR images of our patients revealed symmetrical hyperintense signals in dorsal and lateral columns in T2 weighted series. After treatment with intramuscular B12 injections (1 mg daily for 2 weeks, once weekly thereafter for three months) all patients showed improvement of their symptoms. Abnormalities of the spinal cord on MRI resolved in three months. In conclusion, SCD either due to nitrous oxide exposure or due to reduced intake of vitamin B12 is a reversible condition, when detected and treated early.

scholarly journals Elucidating Unique Axonal Dysfunction Between Nitrous Oxide Abuse and Vitamin B12 Deficiency

2019 ◽  
Vol 10 ◽  
Author(s):  
Jowy Tani ◽  
Hsing-Yu Weng ◽  
Hung-Ju Chen ◽  
Tsui-San Chang ◽  
Jia-Ying Sung ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency ◽  
Axonal Dysfunction

NITROUS OXIDE ANAESTHESIA INDUCED VITAMIN B12 DEFICIENCY PRESENTING AS ACUTE MYELONEUROPATHY

2018 ◽  
Vol 5 (5) ◽  
pp. 330
Author(s):  
Manish Tyagi ◽  
Harshavardhan Sampath ◽  
Geeta Soohinda ◽  
Sanjiba Dutta
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Nitrous Oxide Anaesthesia ◽  
Oxide Anaesthesia ◽  
B12 Deficiency

scholarly journals Skin Hyperpigmentation as the Presenting Symptom of Subacute Combined Degeneration of the Spinal Cord

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Abdulhameed Alhazmi ◽  
Abdulrahman Almalki ◽  
Safieeldin Ghazala
Keyword(s):  
Spinal Cord ◽  
Vitamin B12 ◽  
Vitamin B12 Deficiency ◽  
Neurological Complications ◽  
Subacute Combined Degeneration ◽  
Skin Hyperpigmentation ◽  
B12 Deficiency

Vitamin B12 deficiency results in hematological, neurological, and rarely dermatological complications. Subacute combined degeneration of the cord is one of the neurological complications, and usually the presenting symptom is paresthesia. Herein, we report a case of a 46-year-old man with subacute combined degeneration presenting with knuckle hyperpigmentation.

Myeloneuropathy from Whipped Cream Bulbs Presenting as Conversion Disorder

1997 ◽  
Vol 31 (1) ◽  
pp. 131-132 ◽  
Author(s):  
Adam Brett
Keyword(s):  
Nitrous Oxide ◽  
Vitamin B12 ◽  
Psychiatric Hospital ◽  
Neurological Examination ◽  
Vitamin B12 Deficiency ◽  
Conversion Disorder ◽  
Neurological Symptoms ◽  
Recreational Drug ◽  
B12 Deficiency ◽  
Whipped Cream

Objective:To highlight the complications of nitrous oxide abuse. Clinical picture:A case is presented of a myeloneuropathy in a 21-year-old woman who had been abusing nitrous oxide, obtained from whipped cream bulbs, who was referred to a psychiatric hospital with a diagnosis of conversion disorder. Nitrous oxide toxicity has been reported in medical and dental professions and a few cases of myeloneuropathy due to induced vitamin B12 deficiency have been reported. This would appear to be the first reported case of myeloneuropathy resulting from nitrous oxide abuse from whipped cream propellants as a recreational drug in the community. Treatment:Three doses of intramuscular hydroxy cobalamin (1000 μg) over the course of 1 week. Outcome:Her neurological symptoms and anxiety settled. Conclusions:Nitrous oxide is becoming more popular as a recreational drug; its complications should be noted and a thorough neurological examination performed if abuse is suspected.

scholarly journals Subacute Combined Degeneration with Motor Neuropathy Following Nitrous Oxide Abuse

2021 ◽  
Vol 39 (2) ◽  
pp. 82-84
Author(s):  
Jin Sung Bae ◽  
Jung Im Seok ◽  
Je Wan Lee
Keyword(s):  
Nitrous Oxide ◽  
Magnetic Resonance ◽  
Vitamin B12 ◽  
Nerve Conduction Study ◽  
Nerve Conduction ◽  
Magnetic Resonance Image ◽  
Vitamin B12 Deficiency ◽  
Motor Neuropathy ◽  
Subacute Combined Degeneration ◽  
B12 Deficiency

The neurotoxicity of nitrous oxide (N<sub>2</sub>O) is known to be mainly occurred by interference with action of vitamin B12. A 38-year-old male presented with progressive gait instability after recreational inhalational use of N<sub>2</sub>O for 2 months. Although spine magnetic resonance image showed typical subacute combined degeneration, nerve conduction study showed motor neuropathy that is atypical findings of vitamin B12 deficiency. This case suggests N<sub>2</sub>O-induced neuropathy can develop separately from a vitamin B12 deficiency.

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