Evaluation of an Adaptive Seamless Design for a Phase II/III Clinical Trial in Recurrent Events Data to Demonstrate Reduction in Number of Acute Exacerbations in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Daniela Casula; Andrea Callegaro; Phoebe Nakanwagi; Vincent Weynants; Ashwani Kumar Arora

doi:10.1080/19466315.2020.1764382

Evaluation of an Adaptive Seamless Design for a Phase II/III Clinical Trial in Recurrent Events Data to Demonstrate Reduction in Number of Acute Exacerbations in Patients With Chronic Obstructive Pulmonary Disease (COPD)

Statistics in Biopharmaceutical Research ◽

10.1080/19466315.2020.1764382 ◽

2020 ◽

Vol 12 (3) ◽

pp. 273-278

Author(s):

Daniela Casula ◽

Andrea Callegaro ◽

Phoebe Nakanwagi ◽

Vincent Weynants ◽

Ashwani Kumar Arora

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Clinical Trial ◽

Pulmonary Disease ◽

Recurrent Events ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations ◽

Recurrent Events Data ◽

Seamless Design ◽

Events Data

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Faculty Opinions recommendation of Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718016181.793486606 ◽

2013 ◽

Author(s):

Adam Wanner ◽

Timothy Scialla

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Pulmonary Disease ◽

Glucocorticoid Therapy ◽

Chronic Obstructive ◽

Short Term ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations

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Personalised Variable vs Fixed Dose Systemic Corticosteroid Therapy in Hospitalized Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Prospective, Multicentered, Randomised, Open-Label Clinical Trial

CHEST Journal ◽

10.1016/j.chest.2021.05.024 ◽

2021 ◽

Author(s):

Li Li ◽

Nana Zhao ◽

Xiangyu Ma ◽

Fenfen Sun ◽

Binfeng He ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Clinical Trial ◽

Pulmonary Disease ◽

Systemic Corticosteroid ◽

Fixed Dose ◽

Chronic Obstructive ◽

Open Label ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations ◽

Systemic Corticosteroid Therapy

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Faculty Opinions recommendation of Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718016181.793492222 ◽

2014 ◽

Author(s):

Marc Miravitlles ◽

Arturo Huerta

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Pulmonary Disease ◽

Glucocorticoid Therapy ◽

Chronic Obstructive ◽

Short Term ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations

Get full-text (via PubEx)

Faculty Opinions recommendation of Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease: the REDUCE randomized clinical trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718016181.793479888 ◽

2013 ◽

Author(s):

Alice Turner

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Clinical Trial ◽

Randomized Clinical Trial ◽

Pulmonary Disease ◽

Glucocorticoid Therapy ◽

Chronic Obstructive ◽

Short Term ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations

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A controlled clinical trial to evaluate a personalised treatment approach for the management of acute exacerbations (flare-ups) of chronic obstructive pulmonary disease (COPD)

http://isrctn.com/ ◽

10.1186/isrctn85620156 ◽

2019 ◽

Author(s):

Jørgen Vestbo ◽

Karen Rhodes

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Clinical Trial ◽

Pulmonary Disease ◽

Treatment Approach ◽

Controlled Clinical Trial ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations ◽

Personalised Treatment

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Acute Exacerbations of Chronic Obstructive Pulmonary Disease

10.3109/9780203913000 ◽

2003 ◽

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations

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Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan

Case Medical Research ◽

10.31525/ct1-nct03957577 ◽

2019 ◽

Author(s):

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations

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Faculty Opinions recommendation of Outcomes of noninvasive ventilation for acute exacerbations of chronic obstructive pulmonary disease in the United States, 1998-2008.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.14213961.15729061 ◽

2012 ◽

Author(s):

Stefano Nava ◽

Raffaele Scala

Keyword(s):

United States ◽

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Noninvasive Ventilation ◽

The United States ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Acute Exacerbations

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Faculty Opinions recommendation of Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1697956.9417059 ◽

2011 ◽

Author(s):

Charlotte Bolton

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Systemic Corticosteroids ◽

Acute Exacerbations

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Faculty Opinions recommendation of Antibiotics in addition to systemic corticosteroids for acute exacerbations of chronic obstructive pulmonary disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1697956.1204054 ◽

2010 ◽

Author(s):

Jadwiga Wedzicha ◽

Anant Patel

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Systemic Corticosteroids ◽

Acute Exacerbations

Get full-text (via PubEx)