scholarly journals Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

Gut Microbes ◽  
2022 ◽  
Vol 14 (1) ◽  
Author(s):  
Breanna J Sheahan ◽  
Casey M Theriot ◽  
Jocsa E. Cortes ◽  
Christopher M Dekaney
Keyword(s):  
Stem Cells ◽  
Intestinal Stem Cells ◽  
Antimicrobial Administration

Epithelial Regeneration after Doxorubicin Arises Primarily from Early Progeny of Active Intestinal Stem Cells

2020 ◽  
Author(s):  
Breanna Sheahan ◽  
Ally N. Freeman ◽  
Theresa M. Keeley ◽  
Linda C. Samuelson ◽  
Jatin Roper ◽  
...  
Keyword(s):  
Stem Cells ◽  
Intestinal Stem Cells ◽  
Epithelial Regeneration

scholarly journals Circadian Regulation of Mitochondrial Uncoupling and Lifespan

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 740-741
Author(s):  
Matthew Ulgherait
Keyword(s):  
Stem Cells ◽  
Circadian Rhythm ◽  
Uncoupling Protein ◽  
Intestinal Stem Cells ◽  
Intestinal Stem Cell ◽  
Cellular Respiration ◽  
Circadian Regulation ◽  
Lifespan Extension ◽  
Diet Restriction ◽  
Mitochondrial Uncoupling

Abstract Because old age is associated with defects in circadian rhythm, loss of circadian regulation is thought to be pathogenic and contribute to mortality. We show instead that loss of specific circadian clock components Period (Per) and Timeless (Tim) in male Drosophila significantly extends lifespan. This lifespan extension is not mediated by canonical diet-restriction longevity pathways, but is due to altered cellular respiration via increased mitochondrial uncoupling. Lifespan extension of per mutants depends on mitochondrial uncoupling in the intestine. Moreover, up-regulated uncoupling protein UCP4C in intestinal stem cells and enteroblasts is sufficient to extend lifespan and preserve proliferative homeostasis in the gut with age. Consistent with inducing a metabolic state that prevents over-proliferation, mitochondrial uncoupling drugs also extend lifespan and inhibit intestinal stem cell overproliferation due to aging or even tumorigenesis. These results demonstrate that circadian-regulated intestinal mitochondrial uncoupling controls longevity in Drosophila and suggest a new potential anti-aging therapeutic target.

scholarly journals A novel in vitro survival assay of small intestinal stem cells after exposure to ionizing radiation

2014 ◽  
Vol 55 (2) ◽  
pp. 381-390 ◽  
Author(s):  
Motohiro Yamauchi ◽  
Kensuke Otsuka ◽  
Hisayoshi Kondo ◽  
Nobuyuki Hamada ◽  
Masanori Tomita ◽  
...  
Keyword(s):  
Stem Cells ◽  
Ionizing Radiation ◽  
Intestinal Stem Cells ◽  
Survival Assay ◽  
Small Intestinal ◽  
In Vitro Survival
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