Structure–activity relationship for human cytochrome P450 substrates and inhibitors

Drug Metabolism Reviews ◽

10.1081/dmr-120001391 ◽

2002 ◽

Vol 34 (1-2) ◽

pp. 69-82 ◽

Author(s):

David F. V. Lewis ◽

Sandeep Modi ◽

Maurice Dickins

Keyword(s):

Cytochrome P450 ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Human Cytochrome

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A quantitative structure-activity relationship analysis on a series of alkyl benzenes metabolized by human cytochrome P450 2E1

Journal of Biochemical and Molecular Toxicology ◽

10.1002/jbt.10055 ◽

2003 ◽

Vol 17 (1) ◽

pp. 47-52 ◽

Author(s):

David F. V. Lewis ◽

Craig Sams ◽

George D. Loizou

Keyword(s):

Cytochrome P450 ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Cytochrome P450 2E1 ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity ◽

Human Cytochrome ◽

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Inhibition of human cytochrome P450 2A6 by 7-hydroxycoumarin analogues: Analysis of the structure-activity relationship and isoform selectivity

European Journal of Pharmaceutical Sciences ◽

10.1016/j.ejps.2019.05.022 ◽

2019 ◽

Vol 136 ◽

pp. 104944

Author(s):

Xiaoyi Qi ◽

Tongyi Dou ◽

Zhongqiong Wang ◽

Jianming Wu ◽

Ling Yang ◽

...

Keyword(s):

Cytochrome P450 ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Human Cytochrome ◽

Cytochrome P450 2A6 ◽

Isoform Selectivity

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α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105295 ◽

2021 ◽

pp. 105295

Author(s):

Peng Chen ◽

Shaobing Wang ◽

Chenyang Cao ◽

Wenchong Ye ◽

Meizhu Wang ◽

...

Keyword(s):

Prostate Cancer ◽

Drug Resistance ◽

Cytochrome P450 ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity

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Structure–activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids

Xenobiotica ◽

10.1080/00498254.2019.1675101 ◽

2019 ◽

Vol 50 (6) ◽

pp. 630-639

Author(s):

Supattra Boonruang ◽

Khanistha Prakobsri ◽

Phisit Pouyfung ◽

Aruna Prasopthum ◽

Pornpimol Rongnoparut ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Human Cytochrome ◽

In Vitro Inhibition

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Structure-Activity Relationship and Elucidation of the Determinant Factor(s) Responsible for the Mechanism-Based Inactivation of Cytochrome P450 2B6 by Substituted Phenyl Diaziridines

Drug Metabolism and Disposition ◽

10.1124/dmd.106.011452 ◽

2006 ◽

Vol 34 (12) ◽

pp. 2102-2110 ◽

Author(s):

Yoshimasa Kobayashi ◽

Chitra Sridar ◽

Ute M. Kent ◽

Satish G. Puppali ◽

John M. Rimoldi ◽

...

Keyword(s):

Cytochrome P450 ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Cytochrome P450 2B6 ◽

Structure Activity ◽

Determinant Factor

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Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes

10.1016/s0300-483x(97)00159-5 ◽

1998 ◽

Vol 125 (1) ◽

pp. 31-44 ◽

Author(s):

David F.V. Lewis ◽

Brian G. Lake

Keyword(s):

Cytochrome P450 ◽

Molecular Modelling ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

P450 Isozymes ◽

Cytochrome P450 Isozymes

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New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis

British Journal of Pharmacology ◽

10.1038/sj.bjp.0707173 ◽

2007 ◽

Vol 150 (7) ◽

pp. 932-942 ◽

Author(s):

L E Korhonen ◽

M Turpeinen ◽

M Rahnasto ◽

C Wittekindt ◽

A Poso ◽

...

Keyword(s):

Cytochrome P450 ◽

Three Dimensional ◽

3D Qsar ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Qsar Analysis ◽

Cytochrome P450 2B6 ◽

Structure Activity

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Quantitative structure-activity relationship (QSAR) and three-dimensional QSAR analysis of a series of xanthates as inhibitors and inactivators of cytochrome P450 2B1

Xenobiotica ◽

10.1080/0049825021000012574 ◽

2002 ◽

Vol 32 (12) ◽

pp. 1063-1077 ◽

Author(s):

I. Lesigiarska ◽

I. Pajeva ◽

S. Yanev

Keyword(s):

Cytochrome P450 ◽

Three Dimensional ◽

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Qsar Analysis ◽

Structure Activity

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Novel Hierarchical Classification and Visualization Method for Multiobjective Optimization of Drug Properties: Application to Structure−Activity Relationship Analysis of Cytochrome P450 Metabolism

Journal of Chemical Information and Modeling ◽

10.1021/ci700262y ◽

2008 ◽

Vol 48 (2) ◽

pp. 364-369 ◽

Author(s):

Fumiyoshi Yamashita ◽

Hideto Hara ◽

Takayuki Ito ◽

Mitsuru Hashida

Keyword(s):

Cytochrome P450 ◽

Multiobjective Optimization ◽

Hierarchical Classification ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Visualization Method ◽

Relationship Analysis ◽

Structure Activity

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Structure-activity relationship of phenoxyaniline congener interactions with cytochrome P450 2B enzymes

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2017.11.247 ◽

2018 ◽

Vol 33 (1) ◽

pp. S75

Author(s):

Chao Chen ◽

Jingbao Liu ◽

P. Ross Wilderman ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

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