Structure-Activity Relationship and Elucidation of the Determinant Factor(s) Responsible for the Mechanism-Based Inactivation of Cytochrome P450 2B6 by Substituted Phenyl Diaziridines

Activity Relationship ◽

Cytochrome P450 2B6 ◽

Structure Activity ◽

Determinant Factor

New potent and selective cytochrome P450 2B6 (CYP2B6) inhibitors based on three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis

British Journal of Pharmacology ◽

10.1038/sj.bjp.0707173 ◽

2007 ◽

Vol 150 (7) ◽

pp. 932-942 ◽

Cited By ~ 30

Author(s):

L E Korhonen ◽

M Turpeinen ◽

M Rahnasto ◽

C Wittekindt ◽

A Poso ◽

...

Keyword(s):

Cytochrome P450 ◽

Three Dimensional ◽

3D Qsar ◽

Activity Relationship ◽

Quantitative Structure ◽

Qsar Analysis ◽

Cytochrome P450 2B6 ◽

α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.105295 ◽

2021 ◽

pp. 105295

Author(s):

Peng Chen ◽

Shaobing Wang ◽

Chenyang Cao ◽

Wenchong Ye ◽

Meizhu Wang ◽

...

Keyword(s):

Prostate Cancer ◽

Drug Resistance ◽

Cytochrome P450 ◽

Activity Relationship ◽

A quantitative structure-activity relationship analysis on a series of alkyl benzenes metabolized by human cytochrome P450 2E1

Journal of Biochemical and Molecular Toxicology ◽

10.1002/jbt.10055 ◽

2003 ◽

Vol 17 (1) ◽

pp. 47-52 ◽

Cited By ~ 14

Author(s):

David F. V. Lewis ◽

Craig Sams ◽

George D. Loizou

Keyword(s):

Cytochrome P450 ◽

Activity Relationship ◽

Cytochrome P450 2E1 ◽

Quantitative Structure ◽

Relationship Analysis ◽

Structure Activity ◽

Human Cytochrome ◽

Alkyl Benzenes

Molecular modelling and quantitative structure-activity relationship studies on the interaction of omeprazole with cytochrome P450 isozymes

Toxicology ◽

10.1016/s0300-483x(97)00159-5 ◽

1998 ◽

Vol 125 (1) ◽

pp. 31-44 ◽

Cited By ~ 20

Author(s):

David F.V. Lewis ◽

Brian G. Lake

Keyword(s):

Cytochrome P450 ◽

Molecular Modelling ◽

Activity Relationship ◽

Quantitative Structure ◽

Structure Activity ◽

P450 Isozymes ◽

Cytochrome P450 Isozymes

Quantitative structure-activity relationship (QSAR) and three-dimensional QSAR analysis of a series of xanthates as inhibitors and inactivators of cytochrome P450 2B1

Xenobiotica ◽

10.1080/0049825021000012574 ◽

2002 ◽

Vol 32 (12) ◽

pp. 1063-1077 ◽

Cited By ~ 5

Author(s):

I. Lesigiarska ◽

I. Pajeva ◽

S. Yanev

Keyword(s):

Cytochrome P450 ◽

Three Dimensional ◽

Activity Relationship ◽

Quantitative Structure ◽

Qsar Analysis ◽

Novel Hierarchical Classification and Visualization Method for Multiobjective Optimization of Drug Properties: Application to Structure−Activity Relationship Analysis of Cytochrome P450 Metabolism

Journal of Chemical Information and Modeling ◽

10.1021/ci700262y ◽

2008 ◽

Vol 48 (2) ◽

pp. 364-369 ◽

Cited By ~ 20

Author(s):

Fumiyoshi Yamashita ◽

Hideto Hara ◽

Takayuki Ito ◽

Mitsuru Hashida

Keyword(s):

Cytochrome P450 ◽

Multiobjective Optimization ◽

Hierarchical Classification ◽

Activity Relationship ◽

Visualization Method ◽

Relationship Analysis ◽

Structure-activity relationship of phenoxyaniline congener interactions with cytochrome P450 2B enzymes

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2017.11.247 ◽

2018 ◽

Vol 33 (1) ◽

pp. S75

Author(s):

Chao Chen ◽

Jingbao Liu ◽

P. Ross Wilderman ◽

James R. Halpert

Keyword(s):

Cytochrome P450 ◽

Activity Relationship ◽

Structure Activity ◽

Relationship Of

ChemInform Abstract: Novel Hierarchical Classification and Visualization Method for Multiobjective Optimization of Drug Properties: Application to Structure-Activity Relationship Analysis of Cytochrome P450 Metabolism.

ChemInform ◽

10.1002/chin.200821216 ◽

2008 ◽

Vol 39 (21) ◽

Author(s):

Fumiyoshi Yamashita ◽

Hideto Hara ◽

Takayuki Ito ◽

Mitsuru Hashida

Keyword(s):

Cytochrome P450 ◽

Multiobjective Optimization ◽

Hierarchical Classification ◽

Activity Relationship ◽

Visualization Method ◽

Relationship Analysis ◽

Modeling Chemical Interaction Profiles: II. Molecular Docking, Spectral Data-Activity Relationship, and Structure-Activity Relationship Models for Potent and Weak Inhibitors of Cytochrome P450 CYP3A4 Isozyme

Molecules ◽

10.3390/molecules17033407 ◽

2012 ◽

Vol 17 (3) ◽

pp. 3407-3460 ◽

Cited By ~ 14

Author(s):

Yunfeng Tie ◽

Brooks McPhail ◽

Huixiao Hong ◽

Bruce A. Pearce ◽

Laura K. Schnackenberg ◽

...

Keyword(s):

Cytochrome P450 ◽

Molecular Docking ◽

Spectral Data ◽

Chemical Interaction ◽

Activity Relationship ◽

Molecular Orbital-Based Quantitative Structure-Activity Relationship for the Cytochrome P450-Catalyzed 4-Hydroxylation of Halogenated Anilines

Chemical Research in Toxicology ◽

10.1021/tx00041a002 ◽

1994 ◽

Vol 7 (5) ◽

pp. 590-598 ◽

Cited By ~ 42

Author(s):

Nicole H. P. Cnubben ◽

Sjaak Peelen ◽

Jan-Willem Borst ◽

Jacques Vervoort ◽

Cees Veeger ◽

...

Keyword(s):

Cytochrome P450 ◽

Molecular Orbital ◽

Activity Relationship ◽

Quantitative Structure ◽