scholarly journals Complex Segregation Analysis Provides Compelling Evidence for a Major Gene Underlying Obsessive-Compulsive Disorder and for Heterogeneity by Sex

2000 ◽  
Vol 67 (6) ◽  
pp. 1611-1616 ◽  
Author(s):  
G. Nestadt ◽  
T. Lan ◽  
J. Samuels ◽  
M. Riddle ◽  
O.J. Bienvenu ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Segregation Analysis ◽  
Major Gene ◽  
Compelling Evidence ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Complex Segregation Analysis

Complex Segregation Analysis of Obsessive-Compulsive Disorder in Families with Pediatric Probands

2005 ◽  
Vol 60 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Gregory L. Hanna ◽  
Tasha E. Fingerlin ◽  
Joseph A. Himle ◽  
Michael Boehnke
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Segregation Analysis ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Complex Segregation Analysis

Phenotypic Variability in Obsessive-Compulsive Disorder and Its Relationship to Familial Risk

CNS Spectrums ◽  
1999 ◽  
Vol 4 (6) ◽  
pp. 57-61 ◽  
Author(s):  
David L. Pauls
Keyword(s):  
Cluster Analysis ◽  
Obsessive Compulsive Disorder ◽  
Segregation Analysis ◽  
Genetic Factors ◽  
Age Of Onset ◽  
Phenotypic Variability ◽  
Familial Risk ◽  
Obsessive Compulsive ◽  
Important Data ◽  
Compulsive Disorder

ABSTRACTTwin and family studies of obsessive-compulsive disorder (OCD) have gleaned important data regarding the influence of genetic factors in the development of this disorder. These studies have shown that understanding the importance of genetic factors in OCD is largely dependent upon how the phenotype is classified. The last decade of research has found that substantial variability of symptomatology exists across individuals diagnosed with OCD. Considering this, a number of analyses have been conducted to determine if possible subtypes of OCD exist, including analysis of age of onset, cluster analysis, factor analysis, and segregation analysis. These methodologies, and possibly others, could aid in identifying the genes involved in the development of OCD.

Segregation analysis of obsessive-compulsive disorder using symptom-based factor scores

1999 ◽  
Vol 88 (6) ◽  
pp. 669-675 ◽  
Author(s):  
John P. Alsobrook II ◽  
James F. Leckman ◽  
Wayne K. Goodman ◽  
Steven A. Rasmussen ◽  
David L. Pauls
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Segregation Analysis ◽  
Factor Scores ◽  
Obsessive Compulsive ◽  
Compulsive Disorder
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