Morphology, Cytology, and Fertility of Synthetic Hybrids of Agropyron spicatum x Agropyron dasystachyum-riparium

1965 ◽  
Vol 126 (4) ◽  
pp. 269-275 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Agropyron Spicatum

Natural and Synthetic Hybrids of Agropyron spicatum x Sitanion hystrix

1964 ◽  
Vol 91 (5) ◽  
pp. 396 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Sitanion Hystrix ◽  
Agropyron Spicatum ◽  
Natural And Synthetic

Synthetic Hybrids of Agropyron caespitosum X Agropyron spicatum, Agropyron caninum, and Agropyron yezoense

1969 ◽  
Vol 130 (2) ◽  
pp. 110-116 ◽  
Author(s):  
Douglas R. Dewey
Keyword(s):  
Synthetic Hybrids ◽  
Agropyron Caninum ◽  
Agropyron Spicatum

The Taxonomy and Ecology of Agropyron spicatum and A. inerme

1939 ◽  
Vol 66 (5) ◽  
pp. 327 ◽  
Author(s):  
Rexford F. Daubenmire
Keyword(s):  
Agropyron Spicatum

scholarly journals Computational approach towards the design of artemisinin–thymoquinone hybrids against main protease of SARS-COV-2

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Victor Moreira de Oliveira ◽  
Matheus Nunes da Rocha ◽  
Emanuel Paula Magalhães ◽  
Francisco Rogênio da Silva Mendes ◽  
Márcia Machado Marinho ◽  
...  
Keyword(s):  
Enzyme Inhibitors ◽  
Antiviral Treatment ◽  
Docking Studies ◽  
Hybrid Products ◽  
Main Protease ◽  
The Central Nervous System ◽  
Synthetic Hybrids ◽  
Energy Of Interaction ◽  
Relevant Interaction ◽  
High Absorption

Abstract Background The sanitary emergency installed in the world, generated by the pandemic of COVID-19, instigates the search for scientific strategies to mitigate the damage caused by the disease to different sectors of society. The disease caused by the coronavirus, SARS-CoV-2, reached 216 countries/territories, where about 199 million people were reported with the infection. Of these, more than 4 million died. In this sense, strategies involving the development of new antiviral molecules are extremely important. The main protease (Mpro) from SARS-CoV-2 is an important target, which has been widely studied for antiviral treatment. This work aims to perform a screening of pharmacodynamics and pharmacokinetics of synthetic hybrids from thymoquinone and artemisin (THY-ART) against COVID-19. Results Molecular docking studies indicated that hybrids of artemisinin and thymoquinone showed a relevant interaction with the active fraction of the enzyme Mpro, when compared to the reference drugs. Furthermore, hybrids show an improvement in the interaction of substances with the enzyme, mainly due to the higher frequency of interactions with the Thr199 residue. ADMET studies indicated that hybrids tend to permeate biological membranes, allowing good human intestinal absorption, with low partition to the central nervous system, potentiation for CYP-450 enzyme inhibitors, low risk of toxicity compared to commercially available drugs, considering mainly mutagenicity and cardiotoxicity, low capacity of hybrids to permeate the blood–brain barrier, high absorption and moderate permeability in Caco-2 cells. In addition, T1–T7 tend to have a better distribution of their available fractions to carry out diffusion and transport across cell membranes, as well as increase the energy of interaction with the SARS-CoV-2 target. Conclusions Hybrid products of artemisinin and thymoquinone have the potential to inhibit Mpro, with desirable pharmacokinetic and toxicity characteristics compared to commercially available drugs, being indicated for preclinical and subsequent clinical studies against SARS-CoV-2. Emphasizing the possibility of synergistic use with currently used drugs in order to increase half-life and generate a possible synergistic effect. This work represents an important step for the development of specific drugs against COVID-19.

scholarly journals Influence of molecular weight upon mannosylated bio-synthetic hybrids for targeted antigen presenting cell gene delivery

Biomaterials ◽  
2015 ◽  
Vol 58 ◽  
pp. 103-111 ◽  
Author(s):  
Charles H. Jones ◽  
Akhila Gollakota ◽  
Mingfu Chen ◽  
Tai-Chun Chung ◽  
Anitha Ravikrishnan ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Gene Delivery ◽  
Antigen Presenting Cell ◽  
Synthetic Hybrids ◽  
Antigen Presenting ◽  
Cell Gene

Structured Synthetic Hybrids

2015 ◽  
pp. 411-418
Keyword(s):  
Synthetic Hybrids
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