Leonardo da Vinci on the Human Body. Charles D. O'Malley , J. B. de C. M. Saunders

Isis ◽  
1953 ◽  
Vol 44 (1/2) ◽  
pp. 65-66 ◽  
Author(s):  
George Sarton
Author(s):  
Karina Ambrock ◽  
Bernd Grohe ◽  
Silvia Mittler

Collagen is the most abundant protein in the human body and serves many functions, from mechanical stability and elasticity in tendons and bone, to optical properties, such as transparency and a fine tuned refractive index in the cornea of the eye. Collagen has interested humankind for centuries: Leonardo Da Vinci studied and drew the tendons in the human body precisely in the 15th and 16th century. A look at the literature reveals easily > 200,000 papers. This article reviews oriented type I collagen artificial alignment strategies.


Author(s):  
J. A. Nowell ◽  
J. Pangborn ◽  
W. S. Tyler

Leonardo da Vinci in the 16th century, used injection replica techniques to study internal surfaces of the cerebral ventricles. Developments in replicating media have made it possible for modern morphologists to examine injection replicas of lung and kidney with the scanning electron microscope (SEM). Deeply concave surfaces and interrelationships to tubular structures are difficult to examine with the SEM. Injection replicas convert concavities to convexities and tubes to rods, overcoming these difficulties.Batson's plastic was injected into the renal artery of a horse kidney. Latex was injected into the pulmonary artery and cementex in the trachea of a cat. Following polymerization the tissues were removed by digestion in concentrated HCl. Slices of dog kidney were aldehyde fixed by immersion. Rat lung was aldehyde fixed by perfusion via the trachea at 30 cm H2O. Pieces of tissue 10 x 10 x 2 mm were critical point dried using CO2. Selected areas of replicas and tissues were coated with silver and gold and examined with the SEM.


1910 ◽  
Vol 69 (1782supp) ◽  
pp. 138-140
Author(s):  
Edward P. Buffet
Keyword(s):  
Da Vinci ◽  

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