Molecular Mechanisms of Temperature Adaptation. A Symposium Presented at the Berkeley Meeting of the American Association for the Advancement of Science, 27-29 December 1965. C. Ladd Prosser

1969 ◽  
Vol 44 (2) ◽  
pp. 249-249
Author(s):  
J. N. R. Grainger
Keyword(s):  
Molecular Mechanisms ◽  
American Association ◽  
Temperature Adaptation

Parallel molecular mechanisms for enzyme temperature adaptation

Science ◽  
2021 ◽  
Vol 371 (6533) ◽  
pp. eaay2784
Author(s):  
Margaux M. Pinney ◽  
Daniel A. Mokhtari ◽  
Eyal Akiva ◽  
Filip Yabukarski ◽  
David M. Sanchez ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Interaction Networks ◽  
Temperature Adaptation ◽  
Mechanistic Studies ◽  
Sequence Analyses ◽  
Evolutionary Mechanisms ◽  
Ketosteroid Isomerase ◽  
Physical Mechanisms ◽  
Bacterial Enzyme ◽  
Enzyme Families

The mechanisms that underly the adaptation of enzyme activities and stabilities to temperature are fundamental to our understanding of molecular evolution and how enzymes work. Here, we investigate the molecular and evolutionary mechanisms of enzyme temperature adaption, combining deep mechanistic studies with comprehensive sequence analyses of thousands of enzymes. We show that temperature adaptation in ketosteroid isomerase (KSI) arises primarily from one residue change with limited, local epistasis, and we establish the underlying physical mechanisms. This residue change occurs in diverse KSI backgrounds, suggesting parallel adaptation to temperature. We identify residues associated with organismal growth temperature across 1005 diverse bacterial enzyme families, suggesting widespread parallel adaptation to temperature. We assess the residue properties, molecular interactions, and interaction networks that appear to underly temperature adaptation.

scholarly journals Tumor microenvironment and immunology of ovarian cancer: 12th Biennial Rivkin Center Ovarian Cancer Research Symposium

2019 ◽  
Vol 29 (Suppl 2) ◽  
pp. s12-s15
Author(s):  
Anirban K Mitra ◽  
Yang Yang-Hartwich
Keyword(s):  
Ovarian Cancer ◽  
Cancer Research ◽  
Tumor Microenvironment ◽  
Cancer Biology ◽  
Molecular Mechanisms ◽  
American Association ◽  
Education Session ◽  
Relevant Research ◽  
Research Topics ◽  
Therapy Sessions

The 12th Biennial Ovarian Cancer Research Symposium organized by the Rivkin Center for Ovarian Cancer and the American Association for Cancer Research held on September 13–15, 2018 covered cutting edge and relevant research topics in ovarian cancer biology and therapy. Sessions included detection and prevention, genomics and molecular mechanisms, tumor microenvironment and immunology, novel therapeutics, and an education session. In this article we provide an overview of the key findings presented in the tumor microenvironment and immunology session.

scholarly journals Introduction: the 12th Biennial Rivkin Center Ovarian Cancer Research Symposium

2019 ◽  
Vol 29 (Suppl 2) ◽  
pp. s1-s1
Author(s):  
Nita J Maihle ◽  
Douglas A Levine ◽  
Kiran Dhillon ◽  
Deborah Kay Armstrong
Keyword(s):  
Ovarian Cancer ◽  
Cancer Research ◽  
Tumor Microenvironment ◽  
Molecular Mechanisms ◽  
American Association ◽  
Cancer Genomics ◽  
Novel Therapeutics ◽  
Cancer Tumor

In September 2018, the 12th Biennial Ovarian Cancer Research Symposium was presented by the Rivkin Center for Ovarian Cancer and the American Association for Cancer Research, in Seattle, WA, USA. The 2018 Symposium focused on four broad areas of research: Detection and Prevention of Ovarian Cancer, Genomics and Molecular Mechanisms of Ovarian Cancer, Tumor Microenvironment and Immunology of Ovarian Cancer, and Novel Therapeutics: Response and Resistance of Ovarian Cancer. In addition, a special panel on the 'Role of Advocates in Ovarian Cancer Research’ was featured.

scholarly journals Fungal Dimorphism and Virulence: Molecular Mechanisms for Temperature Adaptation, Immune Evasion, and In Vivo Survival

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Gregory M. Gauthier
Keyword(s):  
Phase Transition ◽  
Immune Evasion ◽  
Molecular Mechanisms ◽  
Temperature Adaptation ◽  
Dimorphic Fungi ◽  
Fungal Dimorphism ◽  
Recent Advances ◽  
Immune Defenses ◽  
Yeast Phase

The thermally dimorphic fungi are a unique group of fungi within the Ascomycota phylum that respond to shifts in temperature by converting between hyphae (22–25°C) and yeast (37°C). This morphologic switch, known as the phase transition, defines the biology and lifestyle of these fungi. The conversion to yeast within healthy and immunocompromised mammalian hosts is essential for virulence. In the yeast phase, the thermally dimorphic fungi upregulate genes involved with subverting host immune defenses. This review highlights the molecular mechanisms governing the phase transition and recent advances in how the phase transition promotes infection.

scholarly journals Molecular mechanisms of temperature adaptation

2015 ◽  
Vol 593 (16) ◽  
pp. 3483-3491 ◽  
Author(s):  
Sviatoslav N. Bagriantsev ◽  
Elena O. Gracheva
Keyword(s):  
Molecular Mechanisms ◽  
Temperature Adaptation
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