A positive contrast, tri-modality tissue marker for breast tumour localization

2007 ◽  
Vol 52 (3) ◽  
pp. N61-N66
Author(s):  
Yangmei Li ◽  
Jian Xiong Wang ◽  
Claire Holloway ◽  
Donald B Plewes
Keyword(s):  
Positive Contrast ◽  
Breast Tumour ◽  
Tumour Localization ◽  
Tissue Marker

Development of an MRI/x-ray/ultrasound compatible marker for pre-operative breast tumour localization

2005 ◽  
Vol 50 (14) ◽  
pp. 3349-3360 ◽  
Author(s):  
Yangmei Li ◽  
Jianxiong Wang ◽  
Claire Holloway ◽  
Donald B Plewes
Keyword(s):  
Breast Tumour ◽  
X Ray ◽  
Tumour Localization

scholarly journals Differences of breast tumour localization and size between supine and prone breast MRI for a surgery perspective

The Breast ◽  
2021 ◽  
Vol 56 ◽  
pp. S40
Author(s):  
C. Civan Kus ◽  
N. Güldoğan ◽  
E. Yılmaz ◽  
C. Ilgın ◽  
M.E. Arıbal
Keyword(s):  
Breast Mri ◽  
Breast Tumour ◽  
Tumour Localization

scholarly journals Identification of residual breast tumour localization after neo-adjuvant chemotherapy using a radioactive 125 Iodine seed

2010 ◽  
Vol 36 (2) ◽  
pp. 164-169 ◽  
Author(s):  
Y.E.A. van Riet ◽  
A.J.G. Maaskant ◽  
G.J. Creemers ◽  
L.J.C. van Warmerdam ◽  
F.H. Jansen ◽  
...  
Keyword(s):  
Adjuvant Chemotherapy ◽  
Breast Tumour ◽  
Tumour Localization ◽  
Neo Adjuvant Chemotherapy

Evaluation of Positive Contrast Arthrography in Canine Cranial Cruciate Ligament Disease

1996 ◽  
Vol 09 (01) ◽  
pp. 10-3 ◽  
Author(s):  
D.N. Aron ◽  
R. Roberts ◽  
J. Stallings ◽  
J. Brown ◽  
C.W. Hay
Keyword(s):  
Articular Surface ◽  
Cruciate Ligament ◽  
Positive Contrast ◽  
Joint Effusion ◽  
Radiographic Evaluation ◽  
Cranial Cruciate Ligament ◽  
Joint Pathology ◽  
Meniscal Pathology ◽  
Cranial Cruciate Ligament Disease ◽  
Better Than

SummaryArthrographic and intraoperative evaluations of stifles affected with cranial cruciate disease were compared. Arthrography did not appear to be helpful in predicting cranial cruciate ligament pathology. The caudal cruciate ligament was consistently not visualized in the arthrograms and was normal at surgery. The menisci were visualized consistently in the arthrograms, but conclusions could not be made as to the benefit of arthrography in predicting meniscal pathology. Arthrography was not helpful in predicting joint capsule and femoral articular surface pathology. Survey radiographic evaluation was better than arthrography in evaluating joint pathology. When cruciate injury is suspected, after history and physical examination, survey radiographs are better than positive contrast arthrograms at supporting the diagnosis.Positive contrast arthrography was evaluated as a diagnostic aid in canine cranial cruciate ligament disease. It did not appear to be useful in predicting joint pathology. With arthrography, both menisci could be visualized and evaluated for abnormalities. Joint effusion and presence of osteophytes evaluated on survey radiographs was better than arthrography in evaluating joint pathology.

Factors Involved In the Plasminogen Activation System in Human Breast Tumours

1994 ◽  
Vol 71 (05) ◽  
pp. 684-691 ◽  
Author(s):  
László Damjanovich ◽  
Csaba Turzó ◽  
Róza Ádány
Keyword(s):  
Epithelial Cells ◽  
Connective Tissue ◽  
Plasminogen Activators ◽  
Breast Tumour ◽  
Plasminogen Activation ◽  
Malignant Tumours ◽  
Plasminogen Activation System ◽  
Activation System ◽  
Malignant Breast ◽  
Pai 1

SummaryThe plasminogen activation system is a delicately balanced assembly of enzymes which seems to have primary influence on tumour progression. The conversion of plasminogen into serine protease plasmin with fibrinolytic activity depends on the actual balance between plasminogen activators (urokinase type; u-PA and tissue type; t-PA) and their inhibitors (type 1 and 2 plasminogen activator inhibitors; PAI-1 and PAI-2). The purpose of this study was to determine the exact histological localization of all the major factors involved in plasminogen activation, and activation inhibition (plasmin system) in benign and malignant breast tumour samples. Our results show that factors of the plasmin system are present both in benign and malignant tumours. Cancer cells strongly labelled for both u-PA and t-PA, but epithelial cells of fibroadenoma samples were also stained for plasminogen activators at least as intensively as tumour cells in cancerous tissues. In fibroadenomas, all the epithelial cells were labelled for PAM. Staining became sporadic in malignant tumours, cells located at the periphery of tumour cell clusters regularly did not show reaction for PAI-1. In the benign tumour samples the perialveolar connective tissue stroma contained a lot of PAI-1 positive cells, showing characteristics of fibroblasts; but their number was strongly decreased in the stroma of malignant tumours. These findings indicate that the higher level of u-PA antigen, detected in malignant breast tumour samples by biochemical techniques, does not necessarily indicate increased u-PA production by tumour cells but it might be owing to the increased number of cells producing u-PA as well. In malignant tumours PAI-1 seems to be decreased in the frontage of malignant cell invasion; i.e. malignant cells at the host/tumour interface do not express PAI-1 in morphologically detectable quantity and in the peritumoural connective tissue the number of fibroblasts containing PAI-1 is also decreased.

scholarly journals Bone morphogenetic proteins, breast cancer, and bone metastases: striking the right balance

2017 ◽  
Vol 24 (10) ◽  
pp. R349-R366 ◽  
Author(s):  
Catherine Zabkiewicz ◽  
Jeyna Resaul ◽  
Rachel Hargest ◽  
Wen Guo Jiang ◽  
Lin Ye
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Bone Morphogenetic Proteins ◽  
Therapeutic Potential ◽  
Current Knowledge ◽  
Breast Tumour ◽  
Cellular Functions ◽  
Foetal Development ◽  
Key Factor ◽  
The Right

Bone morphogenetic proteins (BMPs) belong to the TGF-β super family, and are essential for the regulation of foetal development, tissue differentiation and homeostasis and a multitude of cellular functions. Naturally, this has led to the exploration of aberrance in this highly regulated system as a key factor in tumourigenesis. Originally identified for their role in osteogenesis and bone turnover, attention has been turned to the potential role of BMPs in tumour metastases to, and progression within, the bone niche. This is particularly pertinent to breast cancer, which commonly metastasises to bone, and in which studies have revealed aberrations of both BMP expression and signalling, which correlate clinically with breast cancer progression. Ultimately a BMP profile could provide new prognostic disease markers. As the evidence suggests a role for BMPs in regulating breast tumour cellular function, in particular interactions with tumour stroma and the bone metastatic microenvironment, there may be novel therapeutic potential in targeting BMP signalling in breast cancer. This review provides an update on the current knowledge of BMP abnormalities and their implication in the development and progression of breast cancer, particularly in the disease-specific bone metastasis.

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