scholarly journals Simulated dose painting of hypoxic sub-volumes in pancreatic cancer stereotactic body radiotherapy

2021 ◽  
Vol 66 (18) ◽  
pp. 185008
Author(s):  
Ahmed M Elamir ◽  
Teodor Stanescu ◽  
Andrea Shessel ◽  
Tony Tadic ◽  
Ivan Yeung ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stereotactic Body Radiotherapy ◽  
Dose Painting

scholarly journals Role of Stereotactic Body Radiotherapy in the Treatment of Elderly and Poor Performance Status Patients With Pancreatic Cancer

2017 ◽  
Vol 13 (3) ◽  
pp. 157-166 ◽  
Author(s):  
Lauren M. Rosati ◽  
Joseph M. Herman
Keyword(s):  
Pancreatic Cancer ◽  
Stereotactic Body Radiotherapy ◽  
Group Performance ◽  
Performance Status ◽  
Single Agent ◽  
Locally Advanced ◽  
Poor Performance ◽  
Tumor Control ◽  
Poor Performance Status ◽  
Patient Reported

Literature on the management of nonmetastatic pancreatic ductal adenocarcinoma in patients who are elderly or have poor performance status is sparse. The median survival of this unique cohort of patients is < 6 months, and most patients are only offered single-agent gemcitabine or supportive care. Recently, adding nanoparticle albumin-bound paclitaxel to gemcitabine was shown to improve survival of patients with metastatic disease with Eastern Cooperative Group performance status of 2. Although standard chemoradiotherapy provides long-term locoregional control in locally advanced pancreatic cancer, it is difficult for this group of patients to tolerate 6 weeks of therapy. Stereotactic body radiotherapy (SBRT) can be delivered in only 3 to 5 days, does not require concurrent chemotherapy, and has limited toxicity, and tumor control rates appear to be equivalent to or better than those achieved with standard chemoradiotherapy. Additionally, SBRT has been shown to improve cancer-related pain and patient-reported quality of life. Given the favorable toxicity profile, SBRT seems like an obvious choice for patients who are elderly, have multiple comorbidities, or have poor performance status. Herein, we review the literature on SBRT in this unique patient population and discuss future directions.

SU-E-J-136: Multimodality-Image-Based Target Delineation for Dose Painting of Pancreatic Cancer

2014 ◽  
Vol 41 (6Part8) ◽  
pp. 187-187
Author(s):  
E Dalah ◽  
E Paulson ◽  
B Erickson ◽  
X Li
Keyword(s):  
Pancreatic Cancer ◽  
Dose Painting ◽  
Target Delineation ◽  
Multimodality Image

scholarly journals Stereotactic body radiotherapy for locally-advanced unresectable pancreatic cancer—patterns of care and overall survival

2017 ◽  
Vol 8 (5) ◽  
pp. 766-777 ◽  
Author(s):  
Michael J. Dohopolski ◽  
Scott M. Glaser ◽  
John A. Vargo ◽  
Goundappa K. Balasubramani ◽  
Sushil Beriwal
Keyword(s):  
Pancreatic Cancer ◽  
Overall Survival ◽  
Stereotactic Body Radiotherapy ◽  
Locally Advanced ◽  
Patterns Of Care ◽  
Unresectable Pancreatic Cancer

scholarly journals Quantifying Reoxygenation in Pancreatic Cancer During Stereotactic Body Radiotherapy

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Edward Taylor ◽  
Jitao Zhou ◽  
Patricia Lindsay ◽  
Warren Foltz ◽  
May Cheung ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stereotactic Body Radiotherapy

scholarly journals Dosimetric and radiobiological comparison of treatment plan between CyberKnife and EDGE in stereotactic body radiotherapy for pancreatic cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Zhi-tao Dai ◽  
Li Ma ◽  
Ting-ting Cao ◽  
Lian Zhu ◽  
Man Zhao ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Spinal Cord ◽  
Stereotactic Body Radiotherapy ◽  
Dose Distribution ◽  
Normal Tissue ◽  
Organs At Risk ◽  
Treatment Plan ◽  
Locally Advanced ◽  
Conformity Index ◽  
Homogeneous Dose

AbstractTo perform a comparison of the different stereotactic body radiotherapy (SBRT) plans between the Varian EDGE and CyberKnife (CK) systems for locally advanced unresectable pancreatic cancer. Fifteen patients with pancreatic cancer were selected in this study. The median planning target volume (PTV) was 28.688 cm3 (5.736–49.246 cm3). The SBRT plans for the EDGE and CK were generated in the Eclipse and Multiplan systems respectively with the same contouring and dose constrains for PTV and organs at risk (OARs). Dose distributions in PTV were evaluated in terms of coverage, conformity index (CI), new conformity index (nCI), homogeneity index (HI), and gradient index (GI). OARs, including spinal cord, bowel, stomach, duodenum and kidneys were statistically evaluated by different dose-volume metrics and equivalent uniform dose (EUD). The volume covered by the different isodose lines (ISDL) ranging from 10 to 100% for normal tissue were also analyzed. All SBRT plans for EDGE and CK met the dose constraints for PTV and OARs. For the PTV, the dosimetric metrics in EDGE plans were lower than that in CK, except that D99 and GI were slightly higher. The EDGE plans with lower CI, nCI and HI were superior to generate more conformal and homogeneous dose distribution for PTV. For the normal tissue, the CK plans were better at OARs sparing. The radiobiological indices EUD of spinal cord, duodenum, stomach, and kidneys were lower for CK plans, except that liver were higher. The volumes of normal tissue covered by medium ISDLs (with range of 20–70%) were lower for CK plans while that covered by high and low ISDLs were lower for EDGE plans. This study indicated that both EDGE and CK generated equivalent plan quality, and both systems can be considered as beneficial techniques for SBRT of pancreatic cancer. EDGE plans offered more conformal and homogeneous dose distribution for PTV, while the CK plans could minimize the exposure of OARs.

Stereotactic body radiotherapy (SBRT) in recurrent or oligometastatic pancreatic cancer

2017 ◽  
Vol 193 (6) ◽  
pp. 433-443 ◽  
Author(s):  
E. Gkika ◽  
S. Adebahr ◽  
S. Kirste ◽  
T. Schimek-Jasch ◽  
R. Wiehle ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stereotactic Body Radiotherapy
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