scholarly journals Microbial lipid production by the yeast Lipomyces starkeyi InaCC Y604 grown on various carbon sources

2021 ◽  
Vol 762 (1) ◽  
pp. 012073
Author(s):  
A B Juanssilfero ◽  
P Salsabila ◽  
E Agustriana ◽  
A Andriani ◽  
Fahrurrozi ◽  
...  
Biology ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 885
Author(s):  
Tayvich Vorapreeda ◽  
Bhimabol Khongto ◽  
Chinae Thammarongtham ◽  
Tanawut Srisuk ◽  
Kobkul Laoteng

Microbial lipid production with cost effectiveness is a prerequisite for the oleochemical sector. In this work, genome-wide transcriptional responses on the utilization of xylose and glucose in oleaginous Aspergillus oryzae were studied with relation to growth and lipid phenotypic traits. Comparative analysis of the active growth (t1) and lipid-accumulating (t2) stages showed that the C5 cultures efficiently consumed carbon sources for biomass and lipid production comparable to the C6 cultures. By pairwise comparison, 599 and 917 differentially expressed genes (DEGs) were identified in the t1 and t2 groups, respectively, in which the consensus DEGs were categorized into polysaccharide-degrading enzymes, membrane transports, and cellular processes. A discrimination in transcriptional responses of DEGs set was also found in various metabolic genes, mostly in carbohydrate, amino acid, lipid, cofactors, and vitamin metabolisms. Although central carbohydrate metabolism was shared among the C5 and C6 cultures, the metabolic functions in acetyl-CoA and NADPH generation, and biosynthesis of terpenoid backbone, fatty acid, sterol, and amino acids were allocated for leveraging biomass and lipid production through at least transcriptional control. This study revealed robust metabolic networks in the oleaginicity of A. oryzae governing glucose/xylose flux toward lipid biosynthesis that provides meaningful hints for further process developments of microbial lipid production using cellulosic sugar feedstocks.


2014 ◽  
Vol 189 ◽  
pp. 36-45 ◽  
Author(s):  
Sofia Tsakona ◽  
Nikolaos Kopsahelis ◽  
Afroditi Chatzifragkou ◽  
Seraphim Papanikolaou ◽  
Ioannis K. Kookos ◽  
...  

2021 ◽  
Vol 9 (34) ◽  
pp. 11439-11447
Author(s):  
Emmanuel D. Revellame ◽  
Alex Zappi ◽  
Rafael Hernandez ◽  
Daniel Gang ◽  
William E. Holmes ◽  
...  

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