The influence of time dependence on the model which consists of two qubits interacting with a two-mode electromagnetic field of the parametric amplifier type is investigated. The analytical solution of the wave function is obtained. The quantum Fisher information, entanglement and population inversion for a time-dependent system are analyzed. The photon statistics of a single-mode are quantified by the evolution of the Mandel parameter. Our results showed that there exists a positive relationship between the time-dependent parameter and entanglement. In other words, the time-dependent parameter due to the degree of entanglement is increased. Also, the quantum quantifier is strongly affected by the time-dependent coupling parameter in the absence and presence of the detuning parameter. This enables new parameters to control the degree of entanglement and quantum Fisher information, especially in quantum communication.