Replicative Aging and Gene Expression in Long-Term Cultures of Human Bone Marrow Stromal Cells

2002 ◽  
Vol 8 (6) ◽  
pp. 901-910 ◽  
Author(s):  
Andrea Banfi ◽  
Giordano Bianchi ◽  
Rosario Notaro ◽  
Lucio Luzzatto ◽  
Ranieri Cancedda ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Replicative Aging

scholarly journals Long-Term Safety of Transplanting Human Bone Marrow Stromal Cells into the Extravascular Spaces of the Choroid of Rabbits

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Adi Tzameret ◽  
Sapir E. Kalish ◽  
Ifat Sher ◽  
Lea Twito ◽  
Amilia Meir ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Vision Loss ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Large Animal ◽  
Severe Vision Loss

Incurable neuroretinal degeneration diseases cause severe vision loss and blindness in millions of patients worldwide. In previous studies, we demonstrated that transplanting human bone marrow stromal cells (hBMSCs) in the extravascular spaces of the choroid (EVSC) of the Royal College of Surgeon rats ameliorated retinal degeneration for up to 5 months. Assessing the safety of hBMSC treatment and graft survival in a large animal is a crucial step before initiating clinical trials. Here, we transplanted hBMSCs into the EVSC compartment of New Zealand White rabbits. No immunosuppressants were used. Transplanted cells were spread across the EVSC covering over 80 percent of the subretinal surface. No cells were detected in the sclera. Cells were retained in the EVSC compartment 10 weeks following transplantation. Spectral domain optical coherence tomography (SD-OCT) and histopathology analysis demonstrated no choroidal hemorrhages, retinal detachment, inflammation, or any untoward pathological reactions in any of transplanted eyes or in the control noninjected contralateral eyes. No reduction in retinal function was recorded by electroretinogram up to 10 weeks following transplantation. This study demonstrates the feasibility and safety of transplanting hBMSCs in the EVSC compartment in a large eye model of rabbits.

Ontology analysis of global gene expression differences of human bone marrow stromal cells cultured on 3D scaffolds or 2D films

Biomaterials ◽  
2014 ◽  
Vol 35 (25) ◽  
pp. 6716-6726 ◽  
Author(s):  
Bryan A. Baker ◽  
P. Scott Pine ◽  
Kaushik Chatterjee ◽  
Girish Kumar ◽  
Nancy J. Lin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Global Gene Expression ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
3D Scaffolds ◽  
Cells Cultured

scholarly journals Gene expression profiling of human bone marrow stromal cells with FGFR-3 mutation (K650M) using cDNA microarrays

10.1038/14334 ◽  
1999 ◽  
Vol 23 (S3) ◽  
pp. 53-53
Author(s):  
Libin Jia ◽  
Michael Bittner ◽  
Yidong Chen ◽  
Kris Gooden ◽  
Yuan Jiang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Gene Expression Profiling ◽  
Stromal Cells ◽  
Expression Profiling ◽  
Bone Marrow Stromal Cells ◽  
Cdna Microarrays ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow
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