Endothelial Progenitor Cell Dysfunction in Type 1 Diabetes: Another Consequence of Oxidative Stress?

2005 ◽  
Vol 7 (11-12) ◽  
pp. 1468-1475 ◽  
Author(s):  
Cindy J.M. Loomans ◽  
Eelco J.P. De Koning ◽  
Frank J.T. Staal ◽  
Ton J. Rabelink ◽  
Anton-Jan Van Zonneveld
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Cell Dysfunction

scholarly journals Endothelial Progenitor Cell Dysfunction: A Novel Concept in the Pathogenesis of Vascular Complications of Type 1 Diabetes

Diabetes ◽  
2003 ◽  
Vol 53 (1) ◽  
pp. 195-199 ◽  
Author(s):  
C. J.M. Loomans ◽  
E. J.P. de Koning ◽  
F. J.T. Staal ◽  
M. B. Rookmaaker ◽  
C. Verseyden ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Vascular Complications ◽  
Endothelial Progenitor ◽  
Cell Dysfunction ◽  
Novel Concept

scholarly journals Identification of the Key Genes Involved in the Effect of Folic Acid on Endothelial Progenitor Cell Transcriptome of Patients with Type 1 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Yi Lu ◽  
Qianhong Yang ◽  
Wei Hu ◽  
Jian Dong
Keyword(s):  
Type 1 Diabetes ◽  
Folic Acid ◽  
Endothelial Progenitor Cell ◽  
Cellular Response ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Ppi Networks ◽  
Cell Transcriptome ◽  
Upregulated Genes

Type 1 diabetes (T1D) is one of the most common autoimmune diseases in children. Previous studies have suggested that endothelial progenitor cells (EPCs) might be engaged in the regulating of the biological processes in T1D and folic acid (FA) might be engaged in regulating EPC function. The present study has identified 716 downregulated genes and 617 upregulated genes in T1D EPC cases after treated with FA. Bioinformatics analysis has shown that these DEGs were engaged in regulating metabolic processes, cell proliferation-related processes, bone marrow development, cell adhesion, platelet degranulation, and cellular response to growth factor stimulus. Furthermore, we have conducted and identified hub PPI networks. Importantly, we have identified 6 upregulated genes (POLR2A, BDNF, CDC27, LTN1, RAB1A, and CUL2) and 8 downregulated genes (SHC1, GRIN2B, TTN, GNAL, GNB2, PTK2, TF, and TLR9) as key regulators involved in the effect of FA on endothelial progenitor cell transcriptome of patients with T1D. We think that this study could provide novel information to understand the roles of FA in regulating EPCs of T1D patients.

scholarly journals Benzo[a]pyrene induces oxidative stress and endothelial progenitor cell dysfunction via the activation of the NF-κB pathway

2013 ◽  
Vol 31 (4) ◽  
pp. 922-930 ◽  
Author(s):  
KANGTING JI ◽  
CHENG XING ◽  
FENGCHUN JIANG ◽  
XIAOYAN WANG ◽  
HUIHUI GUO ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Endothelial Progenitor ◽  
Cell Dysfunction

Type 1 Diabetes Mellitus is Associated with Impairment of Late Outgrowth Endothelial Progenitor Cell Function

2008 ◽  
Vol 17 ◽  
pp. S138
Author(s):  
Louise Dunn ◽  
Patrick Lim ◽  
Daniel Sieveking ◽  
Tim Gattorna ◽  
Martin M.K. Ng
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Endothelial Progenitor Cell ◽  
Progenitor Cell ◽  
Cell Function ◽  
Endothelial Progenitor
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